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"I took the Minnesota multiphasic profile test once, and I tested out as paranoid, cyclothymic, neurotic, and schizophrenic. But I also tested out as an incorrigible liar!"
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As far as I know, this is the first direct reference in science fiction to the idea of fighting an enemy or defeating an enemy using biological agents. (Note: I've been informed that T. Mullett Ellis wrote on this topic earlier in ZALMA in 1895; aerial anarchists plot to attack capital cities with anthrax dropped from balloons).
Biological warfare has been around for at least 2500 years. In the sixth century B.C., the Assyrians used rye ergot to poison enemy wells. In the fifth century B.C., Scythian archers dipped their arrows into animal dung to cause wounds to fester.
The Romans were known to use dead animals to foul the water supplies of their enemies. The Tartars of Russia reputedly had the idea of catapulting bodies infected with bubonic plague over the walls of the city of Kaffa; this may have aided the spread of the Black Death in Europe.
During the Indian wars in North America, the British distributed blankets that were taken from known smallpox sufferers. It is true that the Native American population was devastated by diseases introduced by the new settlers; whether or not the British strategy actually spread the disease is not known.
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