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"By the time I can take people out to where Hubble is looking, they won't be human anymore, by a long way."
- Larry Niven

Alpha Plus  
  Intervening in the physical development of humans can result in enhancements.  

"And now," Mr. Foster went on, "I'd like to show you some very interesting conditioning for the Alpha Plus intellectuals. We have a big batch of them on Rack 5. First Gallery level," he called to two boys who had started to go down to the ground floor.

"They're round about Meter 9000," he explained. "You can't really do any useful intellectual conditioning till the foetuses have lost their tails."

From Brave New World, by Aldous Huxley.
Published by Unknown in 1932
Additional resources -

See also this reference to special genetic tampering called E Therapy which can be done in adulthood, resulting in bubbleheads - from Philip K. Dick's 1965 novel The Three Stigmata of Palmer Eldritch.

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Additional resources:
  More Ideas and Technology from Brave New World
  More Ideas and Technology by Aldous Huxley
  Tech news articles related to Brave New World
  Tech news articles related to works by Aldous Huxley

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