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"By the time I can take people out to where Hubble is looking, they won't be human anymore, by a long way."
- Larry Niven

Bone-Building Compounds  
  Combat heavy gravity on other planets by building greater bone density in workers and colonists.  

Earth's scientists solved the problem to some extent by devising rigid metallic clothing not unlike armor which would support the interior human structure against Jupiter's pull. Crane's men were also administered compounds devised by the biochemists for the rapid building of bone to strengthen the skeleton structure...
From A Conquest of Two Worlds, by Edmond Hamilton.
Published by Wonder Stories in 1932
Additional resources -

This is an early use of this idea, which finally came to fruition in real science in the form of medicines like Boniva, a biophosphonate drug used in the prevention and treatment of osteoporosis, which marks a loss of bone mineral density and an increased risk of fracture. Physicians have known about osteoporosis since the early 19th century, but it wasn't until the 1960's that an effective treatment was found.

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Additional resources:
  More Ideas and Technology from A Conquest of Two Worlds
  More Ideas and Technology by Edmond Hamilton
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