First Biolimb Grown In Lab

What appears to be the world's first biolimb, a rat forelimb, has been grown in the lab of Harald Ott of Massachusetts General Hospital in Boston.

(Rat forearm is first biolimb)

The technique behind the rat forelimb dubbed "decel/recel" has previously been used to build heartsMovie Camera, lungs and kidneysMovie Camera in the lab. Simpler organs such as windpipes and voicebox tissue have been built and transplanted into people with varying levels of success...

In the first, decel step short for decellularisation organs from dead donors are treated with detergents that strip off the soft tissue, leaving just the "scaffold" of the organ, built mainly from the inert protein collagen. This retains all the intricate architecture of the original organ. In the case of the rat forearm, this included the collagen structures that make up blood vessels, tendons, muscles and bones.

In the second recel step the flesh of the organ is recellularised by seeding the scaffold with the relevant cells from the recipient. The scaffold is then nourished in a bioreactor, enabling new tissue to grow and colonise the scaffold.

Ott began by suspending the decellularised forelimb in a bioreactor, plumbing the collagen artery into an artificial circulatory system to provide nutrients, oxygen and electrical stimulation to the limb. He then injected human endothelial cells into the collagen structures of blood vessels to recolonise the surfaces of blood vessels. This was important, he says, because it made the vessels more robust and prevented them from rupturing as fluids circulated.

Next, he injected a mixture of cells from mice that included myoblasts, the cells that grow into muscle, in the cavities of the scaffold normally occupied by muscle. In two to three weeks, the blood vessels and muscles had been rebuilt. Ott finished off the limb by coating the forelimbs with skin grafts (Biomaterials,

But would the limb's muscles work? To find out, the team used electrical pulses to activate the muscles and found that the rat's paw could clench and unclench. "It showed we could flex and extend the hand," says Ott.

Scientists have worked on creating bionic limbs, and even to attempt to regenerate limbs before, but this appears to be a first.

The first time I ever read about the idea that it might be possible to regrow limbs was in science fiction writer Frank Herbert's 1972 uneven but highly readable novel The Godmakers, in which a badly injured agent is able to regrow what was lost:

Orne began to show small but steady signs of recovery... they placed him on an atlotl/gibiril regimen, forcing the energy transfer which allowed him to regrow his lost fingers and eye, restore his scalp line and erase the other internal-external damage.
(Read more about Frank Herbert's Atlotl/Gibiril Regimen)

Via NewScientist.

Scroll down for more stories in the same category. (Story submitted 6/4/2015)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Ultrathin Brain Needle Developed At MIT
Putting drugs into a selected cubic millimeter within the living brain.

NASA's 'Armstrong' Soft Wearable Upper Extremity Garment
'Exact same articulation as your shoulder joint, and it holds your muscles out of the way...' - Samuel R. Delany, 1966.

iFlytek Doctor Robot First To Pass Medical Exams
No problem, we'll just use the autodoc.

Watch What People Are Seeing Via Brain Scanning
'had managed to see through the other man's eyes as the other man, all unaware, washed their Zis limousine sixteen hundred meters away...' - Cordwainer Smith, 1958.



Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.






Current News

Soft Robotics - Now With 3D Printed Sensors!
'A series of chemelectric afferent nerve-analogues, which permitted it to gauge to an ounce the amount of pressure necessary to snap a bone...'

AI Tool Lynx Insight And The Cybernetic Newsroom
'The structure,... was once a great homeostatic newspaper, the New York Times. It printed itself directly below us...'

Espresso Telescope Searches For Exoplanets
'These instruments were the wonderful ones our astronomers had perfected.'

Dune Fans! Metal-Organic Frameworks Make Science Fiction Real
'Dew collectors,' he muttered, enchanted by the simple beauty of such a scheme.

Manned Maneuvering Unit From 1984
'The glittering little rocket bolted to the black iron behind him.'

Astronaut Gets Younger In Space
'So what we're looking for now is not an antibiotic - an anti-life drug - but an anti-agathic, an anti-death drug...'

Blockchain Used To Verify Election Results
'Any adult could punch into the phone his or her code, followed by a yes or no.'

IJOP Integrated Joint Operations Platform China's Minority Report?
'All day long the idiots babbled, imprisoned in their special high-backed chairs...'

HushMe Bluetooth Device Reinvents The Hush-A-Phone
'Talking into a hush-a-phone which he had plugged into the telephone jack...'

Ultrathin Brain Needle Developed At MIT
Putting drugs into a selected cubic millimeter within the living brain.

Tesla Semi Truck Now At Work
Why wait? Tesla Semi now hard at work.

Illustris: The Next Generation Of Universe Simulation
'This digital device was ... A machine able literally to contain the Universe Itself...'

Scaly Yet Soft Robotic Snake
Love those robotic sneks.

Cool Tinsley Lunar Unicycle Update
Great update of a timeless classic.

NASA's 'Armstrong' Soft Wearable Upper Extremity Garment
'Exact same articulation as your shoulder joint, and it holds your muscles out of the way...'

Kuri Robot Roams Your Home, Taking Pictures
'Small devices with cameras and sound equipment which could move freely...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise | - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.