First Biolimb Grown In Lab

What appears to be the world's first biolimb, a rat forelimb, has been grown in the lab of Harald Ott of Massachusetts General Hospital in Boston.


(Rat forearm is first biolimb)

The technique behind the rat forelimb dubbed "decel/recel" has previously been used to build heartsMovie Camera, lungs and kidneysMovie Camera in the lab. Simpler organs such as windpipes and voicebox tissue have been built and transplanted into people with varying levels of success...

In the first, decel step short for decellularisation organs from dead donors are treated with detergents that strip off the soft tissue, leaving just the "scaffold" of the organ, built mainly from the inert protein collagen. This retains all the intricate architecture of the original organ. In the case of the rat forearm, this included the collagen structures that make up blood vessels, tendons, muscles and bones.

In the second recel step the flesh of the organ is recellularised by seeding the scaffold with the relevant cells from the recipient. The scaffold is then nourished in a bioreactor, enabling new tissue to grow and colonise the scaffold.

Ott began by suspending the decellularised forelimb in a bioreactor, plumbing the collagen artery into an artificial circulatory system to provide nutrients, oxygen and electrical stimulation to the limb. He then injected human endothelial cells into the collagen structures of blood vessels to recolonise the surfaces of blood vessels. This was important, he says, because it made the vessels more robust and prevented them from rupturing as fluids circulated.

Next, he injected a mixture of cells from mice that included myoblasts, the cells that grow into muscle, in the cavities of the scaffold normally occupied by muscle. In two to three weeks, the blood vessels and muscles had been rebuilt. Ott finished off the limb by coating the forelimbs with skin grafts (Biomaterials, doi.org/4w7).

But would the limb's muscles work? To find out, the team used electrical pulses to activate the muscles and found that the rat's paw could clench and unclench. "It showed we could flex and extend the hand," says Ott.

Scientists have worked on creating bionic limbs, and even to attempt to regenerate limbs before, but this appears to be a first.

The first time I ever read about the idea that it might be possible to regrow limbs was in science fiction writer Frank Herbert's 1972 uneven but highly readable novel The Godmakers, in which a badly injured agent is able to regrow what was lost:

Orne began to show small but steady signs of recovery... they placed him on an atlotl/gibiril regimen, forcing the energy transfer which allowed him to regrow his lost fingers and eye, restore his scalp line and erase the other internal-external damage.
(Read more about Frank Herbert's Atlotl/Gibiril Regimen)

Via NewScientist.

Scroll down for more stories in the same category. (Story submitted 6/4/2015)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Unfurl The Future! Huawei Mate X versus Galaxy Fold
'A paper thin polycarbon screen unfurled silently from the top of the unit and immediately grew rigid.'

Amazon Echo And Google Home Should Have Morality Software
'The Dwoskin Morality Rating-Computer could 'spot the slightest tendency to deviation' from the social norm...'

China Building Robot Wives
'Want a life-companion, a pleasant one?'

China Social Credit System Like State-Run Whuffie
'At least there was no mandatory Whuffie check on the monorail platform...'

Project Soli Radar Gesture Chip Now FCC Approved
'He waved his hand and the circuit switched abruptly.'

Stan, Robot Valet, Will Drag Your Car Away
'He activated the grapple tracks. '

Jibo Home Robot Says Goodbye, Is Killswitched
'It resembles an oyster....'

Johns Hopkins Says Asteroid Deflection Will Be Difficult
'This obelisk is one huge deflector mechanism...'

Fabric Automatically Cools Or Insulates Based On Environment
'...a high-efficiency filter and heat-exchange system.'

Deepfakes From OpenAI GPT-2 Algorithm
'How can you compete with an IBM heavy-duty logomatic analogue?'

John Deere Self-Driving Tractor
'The huge plow... seemed to shake itself - and began to move back southward.'

North Focals Smart Glasses Provide Augmented Reality In Style
'The world ... is drenched in unfamiliar information all the way to the horizon.'

Tesla Driver Caught Napping Behind The Wheel
'Mary Risling settled back for a little nap...'

Hayabusa 2 To Begin Asteroid Mining
'We must dig down, and then doubtless we shall find the metal.'

Ionocraft Drone Powered By Electrohydrodynamic Thrust
'He saw one hiss by him as he rounded the corner, trailing a short whip antenna...'

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.