First Biolimb Grown In Lab

What appears to be the world's first biolimb, a rat forelimb, has been grown in the lab of Harald Ott of Massachusetts General Hospital in Boston.


(Rat forearm is first biolimb)

The technique behind the rat forelimb dubbed "decel/recel" has previously been used to build heartsMovie Camera, lungs and kidneysMovie Camera in the lab. Simpler organs such as windpipes and voicebox tissue have been built and transplanted into people with varying levels of success...

In the first, decel step short for decellularisation organs from dead donors are treated with detergents that strip off the soft tissue, leaving just the "scaffold" of the organ, built mainly from the inert protein collagen. This retains all the intricate architecture of the original organ. In the case of the rat forearm, this included the collagen structures that make up blood vessels, tendons, muscles and bones.

In the second recel step the flesh of the organ is recellularised by seeding the scaffold with the relevant cells from the recipient. The scaffold is then nourished in a bioreactor, enabling new tissue to grow and colonise the scaffold.

Ott began by suspending the decellularised forelimb in a bioreactor, plumbing the collagen artery into an artificial circulatory system to provide nutrients, oxygen and electrical stimulation to the limb. He then injected human endothelial cells into the collagen structures of blood vessels to recolonise the surfaces of blood vessels. This was important, he says, because it made the vessels more robust and prevented them from rupturing as fluids circulated.

Next, he injected a mixture of cells from mice that included myoblasts, the cells that grow into muscle, in the cavities of the scaffold normally occupied by muscle. In two to three weeks, the blood vessels and muscles had been rebuilt. Ott finished off the limb by coating the forelimbs with skin grafts (Biomaterials, doi.org/4w7).

But would the limb's muscles work? To find out, the team used electrical pulses to activate the muscles and found that the rat's paw could clench and unclench. "It showed we could flex and extend the hand," says Ott.

Scientists have worked on creating bionic limbs, and even to attempt to regenerate limbs before, but this appears to be a first.

The first time I ever read about the idea that it might be possible to regrow limbs was in science fiction writer Frank Herbert's 1972 uneven but highly readable novel The Godmakers, in which a badly injured agent is able to regrow what was lost:

Orne began to show small but steady signs of recovery... they placed him on an atlotl/gibiril regimen, forcing the energy transfer which allowed him to regrow his lost fingers and eye, restore his scalp line and erase the other internal-external damage.
(Read more about Frank Herbert's Atlotl/Gibiril Regimen)

Via NewScientist.

Scroll down for more stories in the same category. (Story submitted 6/4/2015)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.' - Frank Herbert, 1972.

First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.

Nanorobots Roam Your Bloodstream, Cleaning It
Too bad they won't have lasers, though...

MIT Ampli Blocks Build Biomedical Devices
Damn it Spock, I'm a doctor not an engineer!

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Ontario Starts Guaranteed Minimum Income
'Earned by just being born.'

Is There Life In Outer Space? Will We Recognize It?
'The antennae of the Life Detector atop the OP swept back and forth...'

Space Traumapod For Surgery In Spacecraft
' It was a ... coffin, form-fitted to Nessus himself...'

Tesla Augmented Reality Hypercard
'The hypercard is an avatar of sorts.'

A Space Ship On My Back
''Darn clever, these suits,' he murmured.'

Biomind AI Doctor Mops Floor With Human Doctors
'My aim was just not to lose by too much.' - Human Physician participant.

Fuli Bad Dog Robot Is 'Auspicious Raccoon Dog' Bot
Bad dog, Fuli. Bad dog.

Las Vegas Humans Ready To Strike Over Robots
'A worker replaced by a nubot... had to be compensated.'

You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.'

Elon Musk Seeks To Create 1941 Heinlein Speedster
'The car surged and lifted, clearing its top by a negligible margin.'

Somnox Sleep Robot - Your Sleepytime Cuddlebot
Science fiction authors are serious about sleep, too.

Real-Life Macau or Ghost In The Shell
Art imitates life imitates art.

Has Climate Change Already Been Solved By Aliens?
'I had explained," said Nessus, "that our civilisation was dying in its own waste heat.'

First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.

VirtualHome: Teaching Robots To Do Chores Around The House
'Just what did I want Flexible Frank to do? - any work a human being does around a house.'

Messaging Extraterrestrial Intelligence (METI) Workshop
SF writers have thought about this since the 19th century.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.