AICAR Exercise In A Pill

AICAR is exercise in a pill for mice; the drug appears to give the couch potato mouse much more stamina.


(Ronald Evans shows vial of exercise in a pill)

The drug appeared to change the physical composition of muscle, essentially transforming the tissue from sugar-burning fast-twitch fibers to fat-burning slow-twitch ones, the same change that occurs in distance runners and cyclists through training, according to research released Thursday.

"You're getting the benefits of exercise without having to do any work," said David Mangelsdorf, a pharmacologist at University of Texas Southwestern Medical Center in Dallas, who was not connected with the research.

Ronald Evans, the lead researcher and a molecular physiologist at the Salk Institute in La Jolla, has been contacted by many athletes in spite of the fact that AICAR does not appear to work in humans at the kinds of doses that mice receive. Evans has already turned over detection protocols to the World Anti-Doping Agency in Montreal just in case.

When sedentary mice were fed the drug daily for four weeks, they were able to run an average of 1,795 feet on a treadmill, 44% farther than mice that had received a placebo.

Mice seem to get all of the great science for strength and stamina; see transgenic mice for details.

Update 05-Aug-2008: As BajaB points out, the Han in Philip Nowlan's Armageddon 2419 A.D. had figured out how to do this:

Yet in spite of the fact that they had to bear their own full weight at all times, they were physically far inferior to the Americans. They lived lives of physical inertia, having machinery of every description for the performance of all labor, and convenient conveyances for any movement of more than a few steps.

Even from the twisted wreckage of this ship I could see that seats, chairs and couches played an extremely important part in their scheme of existence.

But none of the bodies were overweight. They seemed have been the bodies of men in good health, but muscularly much underdeveloped. Wilma explained to me that they had mastered the science of gland control, and of course dietetics, to the point where men and women among them not uncommonly reached the age of a hundred years with arteries and general health in splendid condition.

End update.

From AICAR: Scientists say they've put exercise in a pill; thanks to Moira for the tip on this story, and of course BajaB for the pointer to the reference.

Scroll down for more stories in the same category. (Story submitted 8/2/2008)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Medical ")

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

EXPLORER, The First Total-Body Scanner
'The object is built up of an infinite series of plane layers, at the focus of the ray...' - Jack Williamson, 1930.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Fishy Facial Recognition Now Possible
'Palenkis can identify random line patterns better than any other species in the universe.'

Spicy Tomatoes Created With Genetic Engineering
How about mashed potatoes and brown gravy?

Driverless Hotel Rooms Predicted In 1828
'Did you never see a moving house before?'

Yandex Self-Driving Taxi Is Very Smooth
'The big car was slowing down, its computer brain sensing an exit ahead.'

Shrimp Actually Made Of Algae Is A New Wave Food
Bring in that crop algae.

Cosplay Style Wings Could Work On Moon
'They're lovely! - titanalloy struts as light and strong as bird-bones...'

Tesla Model 3 Has Outside Speaker Grille
Robert Heinlein does it again.

Arizona Luddites Attack Self-Driving Vehicles
'Trucks don't drive by themselves...' Or do they?

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...'

WINE Spacecraft To Extract Water From Asteroids
'Yes, strangely enough there was still sufficient water beneath the surface of Vesta.'

Japanese Swordsmiths Take On Asteroids
'... a tiny, rocket-powered projectile, drove towards the mysterious bulk.'

Saturn's Rings To Vanish, Let's Mine Them While We Can
'...the valuable shards of what had once been satellites.'

Humans Could Take Up A LOT Less Space
We'd have a lot more room for gardening...

Implosion Fabrication Shrinks 3D Objects To Nanoscale
'Carter had watched miniaturization a hundred times...'

GMO Houseplant Cleans Your Air
Removes compounds too small to be captured by a HEPA filter.

Nova Meat Can 3D Print Your Dinner
Printing out chicken nuggets.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.