Implantable Bioengineered Rat Kidney Tested

Bioengineered rat kidneys have successfully produced urine both in a laboratory apparatus and after being transplanted into living animals. Massachusetts General Hospital (MGH) investigators described building functional replacement kidneys on the structure of donor organs from which living cells had been stripped.


(Decellularized rat kidney )
Shown after reseeding with endothelial cells, to repopulate
the organ's vascular system, and neonatal kidney cells.

"What is unique about this approach is that the native organ's architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient's vascular and urinary systems," says Harald Ott, MD, PhD, of the MGH Center for Regenerative Medicine, senior author of the Nature Medicine article. "If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells."

The approach used in this study to engineer donor organs, based on a technology that Ott discovered as a research fellow at the University of Minnesota, involves stripping the living cells from a donor organ with a detergent solution and then repopulating the collagen scaffold that remains with the appropriate cell type in this instance human endothelial cells to replace the lining of the vascular system and kidney cells from newborn rats. The research team first decellularized rat kidneys to confirm that the organ's complex structures would be preserved.

Bioengineered kidneys transplanted into living rats from which one kidney had been removed began producing urine as soon as the blood supply was restored, with no evidence of bleeding or clot formation. The overall function of the regenerated organs was significantly reduced compared with that of normal, healthy kidneys, something the researchers believe may be attributed to the immaturity of the neonatal cells used to repopulate the scaffolding.

"Further refinement of the cell types used for seeding and additional maturation in culture may allow us to achieve a more functional organ," says Ott. "Based on this inital proof of principle, we hope that bioengineered kidneys will someday be able to fully replace kidney function just as donor kidneys do. In an ideal world, such grafts could be produced 'on demand" from a patient's own cells, helping us overcome both the organ shortage and the need for chronic immunosuppression. We're now investigating methods of deriving the necessary cell types from patient-derived cells and refining the cell-seeding and organ culture methods to handle human-sized organs."

Philip K. Dick fans recall the artiforgs from his 1969 novel Ubik, as well as the earlier references like the artificially grown organs from Larry Niven's 1968 novel A Gift from Earth.

Via Eurekalert.

Scroll down for more stories in the same category. (Story submitted 4/17/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

China Accused Of Harvesting Organs From Unwanted Groups
'The death penalty was his immortality, and he would vote the death penalty for any crime at all.' Larry Niven, 1967.

Robothread Robotic Worms Crawling Through Your Brain
Perfect for clot-busting in the human brain. No Raquel Welch and no lasers, though.

Skin Electronics Can Show Electrocardiogram
'... the young men in the streets who applied polyimde OLED body film to their bared shoulders.' - Chen Qiufan, 2019.

Neurodevices For Consumers? Neuroethicists (And Philip K Dick) Say 'Caveat Emptor'
'They tried to use it today and it wouldn't work. No colors and no ceph patterns, neither one...' - Philip K. Dick, 1977.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Entire Planet Modeled In New MS Flight Sim
'CIC uses [it] to keep track of every bit of spatial information that it owns...'

FlyZoo Robot Hotel By Alibaba
'... hotels that specialized in non-human service.'

Implanted Memories Provide Songs To Birds
Finches can't tell the difference.

Robot Tuna Swims As Fast As Nature's Tuna
'With one fluid motion, it surged forward, plunged, and was gone.'

Shapeshifter Robot Is Comprised Of Cobots
'Its lines wavered, flowed, and then painfully reformed. For an interval, the device struggled with itself...'

Google Commits To Fighting Deepfakes
'The program raced up the screen one scan line at a time, subtly smoothing, deleting and coloring.'

China Accused Of Harvesting Organs From Unwanted Groups
'The death penalty was his immortality, and he would vote the death penalty for any crime at all.'

Osmiridium Sounds Like Science Fiction (But It's Not!)
I can't resist science-fictional elements. Especially when they're real.

When Will We See The First Space Hotel?
'The heart of it was a vast hexagonal structure of welded metal, ten miles across...'

SpaceX Starhopper Has Flash Gordon Style
SpaceX makes retro cool spacecraft.

Mindar The Robot Buddhist Priest Offers A Blessing
'Not working is the hardest work of all.'

Does Your Company Need A 'Chief Dreamer'?
As far as the future is concerned 'they're the only experts we have'.

Helios Modular Touch Screen Wall Lights
'The walls and ceiling bore an irregular spacing of illuminum tiles...'

Zephyr Solar-Electric Stratospheric Drone
'The planes flew continuously, twenty-four hours a day...'

Robot Hummingbird Hovers Biomimetically
'With a buzz... it started out on its journey.'

Harvest Water From Air With Sunlight
'The atmosphere yielded its moisture with reluctance.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.