Implantable Bioengineered Rat Kidney Tested

Bioengineered rat kidneys have successfully produced urine both in a laboratory apparatus and after being transplanted into living animals. Massachusetts General Hospital (MGH) investigators described building functional replacement kidneys on the structure of donor organs from which living cells had been stripped.


(Decellularized rat kidney )
Shown after reseeding with endothelial cells, to repopulate
the organ's vascular system, and neonatal kidney cells.

"What is unique about this approach is that the native organ's architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient's vascular and urinary systems," says Harald Ott, MD, PhD, of the MGH Center for Regenerative Medicine, senior author of the Nature Medicine article. "If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells."

The approach used in this study to engineer donor organs, based on a technology that Ott discovered as a research fellow at the University of Minnesota, involves stripping the living cells from a donor organ with a detergent solution and then repopulating the collagen scaffold that remains with the appropriate cell type – in this instance human endothelial cells to replace the lining of the vascular system and kidney cells from newborn rats. The research team first decellularized rat kidneys to confirm that the organ's complex structures would be preserved.

Bioengineered kidneys transplanted into living rats from which one kidney had been removed began producing urine as soon as the blood supply was restored, with no evidence of bleeding or clot formation. The overall function of the regenerated organs was significantly reduced compared with that of normal, healthy kidneys, something the researchers believe may be attributed to the immaturity of the neonatal cells used to repopulate the scaffolding.

"Further refinement of the cell types used for seeding and additional maturation in culture may allow us to achieve a more functional organ," says Ott. "Based on this inital proof of principle, we hope that bioengineered kidneys will someday be able to fully replace kidney function just as donor kidneys do. In an ideal world, such grafts could be produced 'on demand" from a patient's own cells, helping us overcome both the organ shortage and the need for chronic immunosuppression. We're now investigating methods of deriving the necessary cell types from patient-derived cells and refining the cell-seeding and organ culture methods to handle human-sized organs."

Philip K. Dick fans recall the artiforgs from his 1969 novel Ubik, as well as the earlier references like the artificially grown organs from Larry Niven's 1968 novel A Gift from Earth.

Via Eurekalert.

Scroll down for more stories in the same category. (Story submitted 4/17/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Will The FDA Approve This Antiaging Drug?
'So what we're looking for now is... an anti-agathic, an anti-death drug.' - James Blish, 1951.

EVE Artificial Womb For Lambs (For Now)
'In the crimson darkness, stewing warm on their cushion of peritoneum and gorged with blood-surrogate and hormones...' - Aldous Huxley, 1932.

Bees Royal Jelly Helps Wounds Heal Faster
'An alien drug... used by an insect race.' - Clifford Simak, 1961.

3D Printed Bionic Chinese Skin
Designer skin for everyone!

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Eden-ISS, Greenhouse In Antarctica
'With this kind of light we could get the gardens going again."

Make Space Tools On The Spot (Like Moties)
'A moment ago it was squeezing silver toothpaste in a ribbon...'

Will Robots Be Moral If We Raise Them Like Our Children?
'The birth of Machine, my robot child...'

Foldable Galaxy Phones, I Swear They're Coming (Maybe)
How hard can it be?

Bacteria Behave Differently In Space
'The Republic struggled to control its Sours...'

Brain Connected To Internet - ‘Brainternet'
Fascinating!

Artificial Spider Silk
You can also use it to make a roof - on an asteroid.

MIT Tunes Ions For Frictionless Surface - Superlubricity!
'My telelubricator here neutralizes the interatomic bonds the surface of any solid...'

Seiko Astron Always Knows Your Time Zone
'Harrington glanced at his wrist watch - a bulky affair - and whistled.'

Robot Buddhist Priest Chants, Drums
'He crossed the waiting room to the Padre booth...'

Koniku Kore, Mouse Brain-Based Chip, Detects Explosives
'As a matter of fact, this mouse is going to keep on thinking forever.'

CNH Industrial Autonomous Tractor Concept Video
'...the tiny red glints of self-guided tractors.'

The Neuroon Open Sleep Tracker For Lucid Dreaming
'Leads trail away from insertion points on her face and wrist... to a lucid dreamer on the bedside shelf.'

Siri Now Smoother, Perkier (Thanks, Deep Learning!)
'Good morning, Dr. Chandra. This is Hal.'

China's Drone Fleet Flies In Formation
'Programmed to hang... in a hexagonal grid pattern.'

Neuralink, The Latest Elon Musk Passion
'I used my implant to tell MILLIE [a mainframe computer] what we wanted...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.