Youthful Brain With A Flip Of A Molecular Switch

The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now Yale School of Medicine researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.

By monitoring the synapses in living mice over weeks and months, Yale researchers have identified the key genetic switch for brain maturation a study released March 6 in the journal Neuron. The Nogo Receptor 1 gene is required to suppress high levels of plasticity in the adolescent brain and create the relatively quiescent levels of plasticity in adulthood. In mice without this gene, juvenile levels of brain plasticity persist throughout adulthood. When researchers blocked the function of this gene in old mice, they reset the old brain to adolescent levels of plasticity.

“These are the molecules the brain needs for the transition from adolescence to adulthood,” said Dr. Stephen Strittmatter. Vincent Coates Professor of Neurology, Professor of Neurobiology and senior author of the paper. “It suggests we can turn back the clock in the adult brain and recover from trauma the way kids recover.”

Readers of Analog recall the "Kitten" series by Jeffrey D. Kooistra; "Puff" [Analog, December 1993], "Fluffy" [Analog, June 1996], and "Snowball" [Analog, July 1996].

The plot: scientist invents cat that never ages beyond being a kitten. Never-ending kitten-itude leads to constant learning at a high rate leads to hyperintelligent kittens leads to murder.

Via Yale; thanks to Winchell Chung for the tip on the story.

Scroll down for more stories in the same category. (Story submitted 3/27/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 1 )

Related News Stories - (" Biology ")

Mushroom Eats Plastic, Saves Planet
Fungus Amongus, SaveUs!

Is There Extraterrestrial Life Here In The Solar System
'How fast is it moving? ...one meter per minute.' - Arthur C. Clarke, 1982.

Chinese Fern Helps Remediate Arsenic Soil
'Bioengeering had put out a spec report on the long crawly things five months back.' - Gregory Benford, 1983.

New Lifelike Material Powered By Artificial Metabolism
'... The biological robots were not living creatures.' - Arthur C. Clarke, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Orbital Display's Low Earth Orbit Advertisements
'A vast circle of scarlet stars came up into the greenish desert dusk.'

Neuromorphic Computing Hardare
'He had constructed an organ, a brain, of metal, entirely inorganic and lifeless...'

Vascularized Human Skin 3D Printed
Hey Fishboy!

Trillionaires Still Earth-Bound
'I shall never forget the sight... when the yellow gleam of the precious metal appeared under the star dust.'

Digit V2 Bipedal Robot From Agility Robotics
Oh, and now I suppose someone will develop the robotic porch pirate.

3D Printed Dubai Building Is World's Largest
'This thing will start at one end of ...a house and build it complete to the other end, following drawings only.'

Grow Plants On Moon Or Mars!
'In contrast to the airless desolation outside, the interior of this five-acre greenhouse was the one most desirable place to be.'

California Gets Shockwave Rider-Style Avoidance Zones
'It was cheaper to pay the refugees to go without up-to-the-minute equipment.'

Microbot Interstellar von Neumann Explorers
'Evidently they have never had a planet of their own...'

Hail SmartCan! Your Trash Bin Takes Itself Out
'...a waste can twenty feet away stirred into life.'

Finally! Microsoft Surface Neo And Surface Duo Implement Excellent Courier Idea
'Runcible, whose pages were thicker and more densely packed with computational machinery...'

Tap Strap 2 Now With Air Mouse
'He waved his hand and the circuit switched abruptly.'

Legal Profession Now Fairly Bristling With AI
'The virtual counsel appeared to be about forty-five years old and prosperous.'

Entire Planet Modeled In New MS Flight Sim
'CIC uses [it] to keep track of every bit of spatial information that it owns...'

FlyZoo Robot Hotel By Alibaba
'... hotels that specialized in non-human service.'

Implanted Memories Provide Songs To Birds
Finches can't tell the difference.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.