E.T. Mouse Hearts Glow

Researchers at Cornell have created mice whose heart muscles have been genetically engineered to fluoresce when the muscles contract. Junichi Nakai of the RIKEN Brain Science Institute in Wako-shi, Japan, developed the fluorescent molecule by modifying a green fluorescent protein (derived from bioluminescent jellyfish) and making it glow brightly enough to be observed in the working heart. The sensor molecule turns on and off like a switch in the presence of calcium; calcium concentrations in the muscle increase with each muscle contraction.


(Mouse embryo heart fluoresces as it contracts with each beat)

In the graphic shown above, the heart of a mouse embryo goes from a resting state between beats (upper left) through upper heart chamber contraction, then finally lower heart chamber contraction (lower right).

Incredibly, in order to photograph a mouse heart beat (the mouse embryo's heart beats 6-10 times per second), a special camera cooled to -90 degrees Celsius is used to get a sharp image.

By the tenth day of development, a rudimentary heart is already beating, but it has only two chambers. The upper chamber contracts first, then the lower; this delay in contractions is obviously necessary for efficient pumping action. However, the atrio-ventricular node (AV node) does not develop until the thirteenth day; so, how does the heart function without it?

This technique allowed researchers to discover a layer of specialized cells on the surface of the developing heart that delays the beats between upper and lower chambers. These cells die off once the AV node has developed.


(E.T. and Elliot)

This isn't really a case in which science fiction has specifically anticipated a real scientific development, but I couldn't resist the story. In the movie E.T. the Extraterrestrial director Steven Spielberg shows E.T.'s heart glowing as he communicates with his fellows aboard their ship.

For more miraculous mice stories, read Lab Mice Unexpectedly Regenerate Limbs, Organs, Klotho Anti-Aging Mouse Gene and Yoda - The World's Oldest Mouse. Read more about mice with glowing hearts.

Scroll down for more stories in the same category. (Story submitted 3/10/2006)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 1 )

Related News Stories - (" Biology ")

Hackers Insert Malware Into DNA
'They tied the memory to the bloodline and that was their record!' -

Worms Eat Plastic Now
'Slowly and inexorably, the rate of dissolution increased...' - Davis/Pedlar, 1971.

Mini-Brains In A Dish
'Cultured brains on a slab.' - Peter Watts, 1999.

NASA's Prototype Lunar Greenhouse For Mars And Moon
'In contrast to the airless desolation outside, the interior of this five-acre greenhouse was the one most desirable place to be.' - Raymond Z. Gallun, 1951.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Dubai Scorpion Police Hoverbike Ready To Pull Young Kirk Over
'Is there a problem, officer?'

HEXA Robotic Help For Plants
Then some unknown race had chanced upon the dreamers and decided to "help them out."

Korean Tesla Model S Video 'Excelsior' Is Indeed Our Motto
'Improving man by bringing him close to Nature, while they combine the sensations of coasting with the interest of seeing the country well...'

DIY Robot Shoots You In The Face
'...there were automatic guns that fired ligamine darts.'

A Bayesian Approach to Safe Imitation Learning For AIs and Robots
Um, how about that pension for the humans who serve as the models for robot behavior?

Qoobo Headless Robotic Therapy Cat Was Anne McCaffrey's Idea
'...used as surrogates in intense dependency cases.'

Autonomous Cars Talk To Each Other At MCity
'My cars talk to one another.'

PUFFER Robots - From Philip K DIck's Second Variety?
'Across the ground something small and metallic came, flashing in the dull sunlight of midday.'

Russian Space Garden
'We saw the gardens, flooded with artificial sunlight...'

Targeted Neuroplasticity Training For 'Downloading Skills'
'I know kung-fu.'

U of M's MCity To Feature Asimov's Automatobuses
Should you turn autonomous buses off?

Crazyflie Drone Swarm Technology
'...Programmed to hang in space in a hexagonal grid pattern.'

Our GodBot, Who Art In Cyberspace
Vaal hungers! We must serve him.

easyJet Short-Haul Electric Jets
Have a little faith, will you? They're working on it.

Meet Assist-e Honda's Self-Balancing Motorcycle
'He had never ridden any motorized device that lacked onboard steering and balance systems...'

Kalashnikov's One-Seater Hovercraft
Not for windy days.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.