Klotho Anti-Aging Gene

Klotho, a gene in both mice and men, has a definite effect on aging, according to Dr. Makoto Kuro-o. Stimulating the Klotho gene seems to delay many of the effects of old age, like weakening of bones, clogging of the arteries and loss of muscle fitness.


(From Klotho anti-aging mouse gene)

For their current study, Kuro-o and colleagues created a strain of mice in which the Klotho gene is more active than in normal mice. The mice lived between 19% and 31% longer than normal mice.

Dr. Kuro-o writes;

To understand the mechanism by which Klotho suppresses aging, my laboratory is focused on determining specific activity of Klotho protein and identifying molecules that interact with Klotho. The klotho mouse is the first laboratory animal model of human aging caused by a single gene mutation. Studies on the klotho mouse and the klotho gene are thus expected to provide new insights into human aging.

An interesting note is that it appears that the Klotho-enhanced mice who are more long-lived seem to have fewer offspring as a side effect. Also, the effect of Klotho on insulin could create a problem because it may extend life at the expense of making people diabetic.

Mice with the Klotho gene are not the first to help human beings achieve longer life; read about Yoda, the world's oldest mouse and the Methuselah Mouse 'M' Prize.

Science fiction authors have been interested in technologies that might lengthen human life; almost invariably, each of these methods also has a particular flaw. Kurt Vonnegut wrote about anti-gerasone in his well-known short story Tomorrow and Tomorrow and Tomorrow. Anti-gerasone's flaw was that it worked too well - neither material goods nore inheritance laws could keep up.

In A World Out Of Time, Larry Niven writes about a drug called young-forever, which puts off death almost forever. Unfortunately, it works only with children, who then never go through puberty.

The desire to live forever, and the belief that it will never quite work out, of course predates science fiction authors. The ancient Greeks wrote about the goddess Eos, who fell in live with a mortal man, Tithonus; she asked Zeus to grant him immortality. Zeus did so, but Eos forgot to ask for eternal youth; Tithonus lived on and on, eventually withering into a shrill grasshopper.

And, as it happens, the name "Klotho" is also derived from the Greek myths. Klotho combed and spun the thread of one's life, Atropos wove the thread into the fabric of one's actions, and Lachesis snipped the thread at death.

Find out more about Dr. Makoto Kuro-O and Anti-aging protein extends mouse lifespan.

Scroll down for more stories in the same category. (Story submitted 8/29/2005)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 2 )

Related News Stories - (" Medical ")

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...' - Larry Niven, 1968.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

Wound Healing With Wearable Nanogenerators
'... forcing the energy transfer which allowed him to ... erase the other internal-external damage.' - Frank Herbert, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

North Focals Smart Glasses Provide Augmented Reality In Style
'The world ... is drenched in unfamiliar information all the way to the horizon.'

Tesla Driver Caught Napping Behind The Wheel
'Mary Risling settled back for a little nap...'

Hayabusa 2 To Begin Asteroid Mining
'We must dig down, and then doubtless we shall find the metal.'

Ionocraft Drone Powered By Electrohydrodynamic Thrust
'He saw one hiss by him as he rounded the corner, trailing a short whip antenna...'

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.'

BloxVox Mutes Cellphone Convos
It's the polite thing to do, and has been the polite thing to do for about four generations.

Superfast Replicator: Volumetric Additive Manufacturing
I can't wait. Bring it on.

DNA May Contain Malware
'You were told to embed the logical pathogen.'

I Can't Resist Worm Robots
'Seen close it was not completely flexible...'

Rplate Digital License Plates Now Legal In Michigan
'Gragg's digital ink license plates ...'

Can Musk Starship Astronauts Use Magnetic Boots?
'Walking awkwardly in the magnetic boots that held him to the black mass of meteoric iron...'

Giant Dolphin Spotted On Jupiter!
'Now at last he could appreciate its real size and complexity...'

Musk's Starship An SF Fan's Dream Come True
Perfect for testing, perfect for fans!

TinyMobileRobots Are Sewer Sentinels
Every movie monster gets its start someplace.

Fishy Facial Recognition Now Possible
'Palenkis can identify random line patterns better than any other species in the universe.'

Spicy Tomatoes Created With Genetic Engineering
How about mashed potatoes and brown gravy?

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.