Researchers Create Bowls, Coils, Ripples Of Living Tissue

Living tissue in a variety of shapes can be created programmatically by UC San Francisco researchers.


(Shapes made of living tissue)
This image shows the shapes made of living tissue, engineered by the researchers. By patterning mechanically active mouse or human cells to thin layers of extracellular fibers, the researchers could create bowls, coils, and ripple shapes. (credit: Alex Hughes)

Many of the complex folded and curved shapes that form human tissues can now be programmatically recreated with very simple instructions, UC San Francisco (UCSF) bioengineers report December 28 in the journal Developmental Cell. The researchers used 3D cell-patterning to shape active mouse and human embryonic cells into thin layers of extracellular matrix fibers (a structural material produced by human cells that make up our connective tissue) to create bowls, coils, and ripples out of living tissue. A web of these fibers folded themselves up in predictable ways, mimicking developmental processes in natural human body tissue.

The UCSF lab approach instead used a precision 3D cell-patterning technology called DNA-programmed assembly of cells (DPAC). It provides an initial template (pattern) for tissue to later develop in vitro (in a test tube or other lab container). That tissue automatically folds itself into complex shapes in ways that replicate how in vivo (body) tissues normally assemble themselves hierarchically during development.

“This approach could significantly improve the structure, maturation, and vascularization” of tissues in organoids” (miniature models of human parts, such as brains, used for drug testing) “and 3D-printed tissues in general,” the researchers note in the paper.

Science fiction author Arthur C. Clarke told us (and me, since I read this book when it came out) about this idea in 1972, in his still-current novel Rendezvous With Rama; he used a much more compact word - biot - to describe them:

...now life, with all its infinite possibilities, had come to Rama. If the biological robots were not living creatures, they were certainly very good imitations.

No one knew who invented the word "biot"; it seemed to come into instant use, by a kind of spontaneous generation.
(Read more about Clarke's biots)

The term was used to describe creations like the spider tripod robots that Rama seemed to spontaneously generate for self-cleaning whenever an energy source (a sun) became available.

Via KurzweilAI.

Scroll down for more stories in the same category. (Story submitted 4/9/2018)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Biology ")

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.

Researchers Create Bowls, Coils, Ripples Of Living Tissue
'... biological robots were not living creatures.' - Arthur C. Clarke, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Swarm Of Mindless Robots Works Together
'Very tiny pseudo insects that... can unite to form a superordinate system.'

SpotMini Robot Dog, Autonomous And On Sale In 2019
Great, an autonomous slamhound. It is cute, though.

RoboFly Is Laser-Powered, Adorable
Don't swat this fly!

MSG Sphere Las Vegas, ala Star Wars
'The smoky globe, hung in the vault, was shot with colored light...'

Tetraplegics Dominate Avatar Races
Well, just speaking brain-to-computer...

MIT Ampli Blocks Build Biomedical Devices
Damn it Spock, I'm a doctor not an engineer!

UberAIR Asks For Skytaxi Landing Prototypes
You know you want to ride in one.

Boring Tunnel Almost Ready
Your underground future is calling!

Handheld Human Skin Printer
It outputs a thin wad of uniflesh.

Healthy Fast Food Courtesy Of Robot Chefs
'The electric cook was stirring empty nothing in a pan, with a zeal worthy a dozen eggs.'

Mass Production Of In Vitro Meat From One Sample
They're Assimilating Our Culture, That's What They're Doing

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Retinal Prosthesis Uses Organic Printing Inks
We can rebuild you - well, your eyes, maybe.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

Squid-Like Robots Soon To Be 3D Printable
'It was a chemotactic artificial jellyfish designed to slither...'

Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.