Engineered Bacteria Produces Gasoline

Is there a way to manufacture gasoline, rather than trying to find a limited resource in nature?

In the paper (entitled "Microbial Production of Short-chain Alkanes") published online in Nature on September 29, a Korean research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST) reported, for the first time, the development of a novel strategy for microbial gasoline production through metabolic engineering of E. coli.

The research team engineered the fatty acid metabolism to provide the fatty acid derivatives that are shorter than normal intracellular fatty acid metabolites, and introduced a novel synthetic pathway for the biosynthesis of short-chain alkanes. This allowed the development of platform E. coli strain capable of producing gasoline for the first time. Furthermore, this platform strain, if desired, can be modified to produce other products such as short-chain fatty esters and short-chain fatty alcohols.

Professor Sang Yup Lee said, "It is only the beginning of the work towards sustainable production of gasoline. The titer is rather low due to the low metabolic flux towards the formation of short-chain fatty acids and their derivatives. We are currently working on increasing the titer, yield and productivity of bio-gasoline. Nonetheless, we are pleased to report, for the first time, the production of gasoline through the metabolic engineering of E. coli, which we hope will serve as a basis for the metabolic engineering of microorganisms to produce fuels and chemicals from renewable resources."

In his 1950 novel Needle, Hal Clement wrote about culture tanks that would accomplish this feat:

"They call 'em culture tanks. They have bugs -- germs -- growing in them; germs that eat pretty near anything, and produce oil as a waste product. That's the purpose of the whole business. We dump everything that's waste into the tanks, pump the oil off the top, and every so often clean the sludge out of the bottom -- that's a nasty job."
(Read more about Hal Clement's culture tank)

Via University Herald.

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