Can Sirtuins Block The Aging Process?

SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches such as FOXO3a and PGC-1a.

“At the cellular level,” explain the authors. “SIRT1 controls DNA repair and apoptosis, circadian clocks, inflammatory pathways, insulin secretion, and mitochondrial biogenesis”

Resveratrol (a polyphenol found in red wine and grapes) may be a weak natural activator of sirutin and has been linked in some studies with the extension of animal lifespan. Data on these sitruin activators or STACs is inconsistent. “The legitimacy of STACs as direct SIRT1 activators has been widely debated,” write the authors.

In the present study, the researchers developed a sirtuin activation assay. They tested 117 experimental STACs and were able to prove that the enzyme could be directly activated and uncovered the exact molecular mechanism by which this occurred.

The authors conclude:

The data presented here favor a mechanism of direct “assisted allosteric activation” mediated by an N-terminal activation domain in SIRT1 that is responsible for at least some of the physiological effects of STACs. Thus, allosteric activation of SIRT1 by STACs remains a viable therapeutic intervention strategy for many diseases associated with aging.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says Sinclair, from Harvard University. “In effect, they would slow ageing.” He points out this research shows something never previously described ”In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” he said.

Sinclair believes that safe drugs of this class could be available for testing in as little as five years.

Mankind has wished for a Fountain of Youth for a long time. Science fiction writers have expressed their longing for a scientific basis to anti-aging. One such example is the Sprung-Samser treatment from Roger Zelazny's 1966 novel This Immortal:

Eighty or ninety or more, looking about forty, [Hasan] could still act thirty. the Sprung-Samser treatments had found highly responsive material. It's not often that way. Almost never, in fact. They put some people into accelerated anaphylactic shock for no apparent reason, and even an intracardial blast of adrenalin won't haul them back; others, most others, they freeze at five or six decades. But some rare ones actually grow younger when they take the series - about one in a hundred thousand.

Fans of the Cities in Flight novels by James Blish may recall the anti-agathic drugs that were provided to a select few members of the cities.

From Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators via Extreme Longevity.

Scroll down for more stories in the same category. (Story submitted 3/10/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

iFlytek Doctor Robot First To Pass Medical Exams
No problem, we'll just use the autodoc.

Watch What People Are Seeing Via Brain Scanning
'had managed to see through the other man's eyes as the other man, all unaware, washed their Zis limousine sixteen hundred meters away...' - Cordwainer Smith, 1958.

PRIMA Bionic Vision Restoration
'The VISOR... was a medical device used in the Federation to aid patients who have suffered loss of eyesight...'

Targeted Neuroplasticity Training For 'Downloading Skills'
'I know kung-fu.'

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

China Melts Tibetan Permafrost To Plant Forest
'Can you give us a microwave spotlight?'

iFlytek Doctor Robot First To Pass Medical Exams
Doctor shortage? No problem, we'll just use the autodoc.

Slaughterbot AI KIller Quadcopter Drones
'The real border was defended by... a swarm of quasi-independent aerostats.'

Do We Really Want Backflipping Robots?
Also includes wonderful blooper reel.

RNA-Based Biocomputing Device
Living things can sense and analyze complex signals in living cells.

Seasteading Floating Cities
'It was a remarkable island, circular, about half a kilometer in diameter.'

Tesla Semi 'Electrotruck' Unveiled
Elon Musk unveils yet another technological marvel.

Watch What People Are Seeing Via Brain Scanning
'had managed to see through the other man's eyes as the other man, all unaware, washed their Zis limousine sixteen hundred meters away...'

Integrated Circuits Printed Right Onto Fabric!
'...a shirt that displayed email on its sleeve.

Interstellar Asteroid Visits Our Solar System
'This asteroid had whirled in from the cold of the interplanetary space...'

PRIMA Bionic Vision Restoration
'The VISOR... was a medical device used in the Federation to aid patients who have suffered loss of eyesight...'

Audi Traffic Jam Pilot Knows If You're Sleeping
'Even here, riding a garbage truck to eternity, the machine watched him...'

UM Hall Thruster Breaks Records
Someday, we'll see an ion drive used to get to Mars.

Ionity Ultra-fast Charging Station Network
'Recharge the batteries... in almost every town and village...'

VAuth Voice Security Wearable From University of Michigan
'Siri, I gave you a voice command...' 'Yes, but do I know you?'

Ubiquiti FrontRow Camera Records Your Life
Why be choosy? Just upload your whole life to the Internet, and be done with it.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.