Can Sirtuins Block The Aging Process?
SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches such as FOXO3a and PGC-1a.
“At the cellular level,” explain the authors. “SIRT1 controls DNA repair and apoptosis, circadian clocks, inflammatory pathways, insulin secretion, and mitochondrial biogenesis”
Resveratrol (a polyphenol found in red wine and grapes) may be a weak natural activator of sirutin and has been linked in some studies with the extension of animal lifespan. Data on these sitruin activators or STACs is inconsistent. “The legitimacy of STACs as direct SIRT1 activators has been widely debated,” write the authors.
In the present study, the researchers developed a sirtuin activation assay. They tested 117 experimental STACs and were able to prove that the enzyme could be directly activated and uncovered the exact molecular mechanism by which this occurred.
The authors conclude:
The data presented here favor a mechanism of direct “assisted allosteric activation” mediated by an N-terminal activation domain in SIRT1 that is responsible for at least some of the physiological effects of STACs. Thus, allosteric activation of SIRT1 by STACs remains a viable therapeutic intervention strategy for many diseases associated with aging.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says Sinclair, from Harvard University. “In effect, they would slow ageing.” He points out this research shows something never previously described ”In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” he said.
Sinclair believes that safe drugs of this class could be available for testing in as little as five years.
Mankind has wished for a Fountain of Youth for a long time. Science fiction writers have expressed their longing for a scientific basis to anti-aging. One such example is the Sprung-Samser treatment from Roger Zelazny's 1966 novel This Immortal:
Eighty or ninety or more, looking about forty, [Hasan] could still act thirty. the Sprung-Samser treatments had found highly responsive material. It's not often that way. Almost never, in fact. They put some people into accelerated anaphylactic shock for no apparent reason, and even an intracardial blast of adrenalin won't haul them back; others, most others, they freeze at five or six decades. But some rare ones actually grow younger when they take the series - about one in a hundred thousand.
Fans of the Cities in Flight novels by James Blish may recall the anti-agathic drugs that were provided to a select few members of the cities.
From Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators via Extreme Longevity.
Scroll down for more stories in the same category. (Story submitted 3/10/2013)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Bioreactor Helps Legless Frogs Get Their Jump Back
'An alien drug... Used by an insect race... It can repair bones and organs. It can grow new tissue." - Clifford Simak, 1961
Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.' - Arthur C. Clarke, 1963.
You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.' - Frank Herbert, 1972.
First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
Drywall Robot Looking For Sheetrock
Sheetrockers have sure changed since my day.
Ford's Autonomous Cabs 'Transportation As A Service'
'He was glad to crawl into his autocab and close the cover.'
Sex In Driverless Cars?
'...admirable for petting.'
Amazing Kepler Space Telescope Decommissioned By NASA
'Thus it came about that the search for a planetiferous sun... was not unduly prolonged...'
ODYSSEUS Solar-Powered Stratospheric Plane Flies Forever
'The planes flew continuously, twenty-four hours a day...'
Augmented and-or Virtual Reality Shoes From Google
'The auto-treadmill's bumps and gullies matched whatever terrain the goggles showed me...'
Soon, Your Tesla Will Follow You Like A Pet
'... follow him as faithfully as a well-trained hound.'
Chinese Watrix Gait Recognition Watching You Always
'... those pesky gait-recognition cameras.'
FlexPai Foldable Phone By Royole
'...A paper thin polycarbon screen unfurled.'
Oh Yes, We're Building The Rotating Tower In Dubai
'Give me an old-fashioned tetragon on a central pivot every time.'
Bioreactor Helps Legless Frogs Get Their Jump Back
'An alien drug... Used by an insect race... It can repair bones and organs. It can grow new tissue."
Xinhua AI Anchor Puts CGI Face To Automated News
'...a congeries of software agents.'
Wirewax Watching You Watch, Adjusting Your Experience
'He adjusted the n, the r and b knobs, and hopefully anticipated a turn for the better...'
LawGeex AI Beats 20 Top Lawyers
'The Law Society has strict rules on the use of pseudo-intelligent software - terrified of putting... its members out of work.'
ROAM Robotics Skiing Exoskeleton
'The real genius in the design is that you don't have to control the suit; you just wear it...'
MIT Headset Lets You Communicate Without Speaking
'The subvocal read nerve signals, letting her enter words by just beginning to will them...'
More SF in the News Stories
More Beyond Technovelgy science news stories