Limb Regeneration Grows Closer

How does limb regeneration work in animals like salamanders? If you cut off their tails, they are able to completely recreate the missing limb, including bones, muscle, skin, blood vessels and nerves.

In salamanders, new tissues come from a tumorlike mass of cells that forms at the site of the injury, called the blastema. Until now, most scientists thought that the blastema contained a population of stem cells that had become pluripotent--capable of giving rise to all the needed tissues.

However, new research published in Nature seems to indicate that the mechanism is simpler than previously supposed. An experiment designed by Elly Tanaka at the Center for Regenerative Therapies, in Dresden, Germany employed a new method for tracking what happens in the axolotl when it is injured.


( Schwann cells are shown here in a salamander limb )

The researchers first created transgenic axolotls that carried green fluorescent protein (GFP) in their entire bodies. When the animals were still embryos, the researchers removed a piece of tissue from the limb region of the transgenic animals and transplanted the tissue into the same location in nontransgenic axolotls. The transplants were incorporated into the growing body as normal cells, and when the limb of the transplant recipients were then severed, the researchers could track the fate of the fluorescent cells as the limb regrew.

The researchers used this method to track the fate of cells of the inner and outer skin, muscles, and cartilage, as well as Schwann cells, which insulate nerve fibers. They found that, contrary to previous evidence, muscle cells at the amputation site only become muscle cells in the new limb. Other cell types also stuck to their previous identities; the only exception, Tanaka says, is that cells of the inner layers of skin and cartilage seem to be able to transform into one another.

Frank Herbert wrote about the idea of limb regeneration in his appropriately named "axolotl tank" from his 1969 novel Dune Messiah:

"Even in defeat," Edric said, "your father's Sardaukar did not abandon wisdom. Let us suppose a wise Sardaukar commander recognized the swordmaster in a corpse his men had slain. What then? There exist uses for such flesh and training . . . if one acts swiftly..."

"A Tleilaxu ghola," Irulan whispered...

...Edric said. "...let us assume that our wise Sardaukar commander had Idaho's corpse preserved for the axolotl tanks.
(Read more about Herbert's axolotl tank)

From MIT's Technology Review.

Scroll down for more stories in the same category. (Story submitted 7/3/2009)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 5 )

Related News Stories - (" Medical ")

DxtER! Tricorder Prize Won By Final Frontier Medical Devices
We've been waiting a long time for this, Star Trek fans.

Dune Fans! Your God Emperor Is Ready
'If one held a sandtrout in the hand, smoothing it over your skin, it formed a living glove.' - Frank Herbert, 1976.

H-MEX Helpful Exoskeleton From Hyundai
'We have those new suits rigged with atomic-powered lifting gadgets...' - John W. Campbell, 1938.

3D Skin Printer Helps Burn Victims
'Over her lacerated right shoulder he sprayed art-derm...'- Philip K. Dick, 1960.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Cattle Avoidance Feature In Indian Autonomous Cars
'The driver went about the business of gently slipping the teflon-coated metal scoop beneath the first animal...'

Project KOVR Fashion Protection From Infosphere
'... the entire shroudlike membrane took on whatever physical characteristics were projected at any nanosecond.'

Twist Bioscience High Density Digital Data On DNA
'They tied the memory to the bloodline and that was their record!'

'We're Not Creating A Terminator' Say Russians About Gun-Wielding Robot Fedor
Nobody is thinking about the Terminator. Westworld, maybe.

Vantablack Now IMMEASURABLY Black
'a black coating now thatís ninety-nine percent absorptive...'

Mercedes-Benz Autonomous Taxi Fleet In 3 Years
'... the taxi utilized sophisticated electronic sensors to perceive its surroundings.'

Is 'The Pulsar Positioning System' Evidence For SETI?
'For a hyperspace jump, you need at least four beacons for an accurate fix.'

Someday, You Might Like VR Enough To Move In
'That barrier was going to melt away someday soon. The transhumanists had promised...'

Humans Use Mental Power For Turtle Slavery
Now we need to start looking for animals with fingers...

Solar-Powered Moisture Vaporator
'The atmosphere yielded its moisture with reluctance.'

DxtER! Tricorder Prize Won By Final Frontier Medical Devices
We've been waiting a long time for this, Star Trek fans.

President Trump's Wall As Otra Nation Hyperloop
'...an hollow tube must be constructed the whole distance... as to admit a four wheeled carriage...'

Pickup Lines From Artificial Intelligences
'They hate us, you know... The humans. They'll stop at nothing.'

Pooper Scooper Drone Robot Watchdog 1
'Robots pick up the garbage and junk...'

Cassie Robot Brings AT-ST Walker To Life
There's even a log test!

Hundreds Of Robot Lawnmowers Invade Texas Town
'The mower reached the edge of the lawn, clucked to itself...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.