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"I realized there was a heavy-duty change coming in biology, and I could write a really compelling novel about catastrophic evolution, punctuated equilibrium."
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Although this is a fairly early sf reference, the first machine to replace the heart in circulating blood to the body was created in 1952 and used successfully in several different procedures. Prototypes used successfully in animals date from 1949.
Here's another description, this time detailing the installation process:
Dick implies that the mechanical heart is effectively a robot; it is a self-regulating device.
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