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Anti-Viral Polymer Paints Flu Into A Corner

A remarkable anti-viral polymer can be applied like paint; it was developed by MIT's Alexander Klibanov. His intent is to develop a biocidal "paint" that can help reduce the spread of germs in public areas and hospitals.


(Bottom slide covered with alkylated PEI)

In the above illustration, a regular commercial glass slide (top) and another one coated with alkylated PEI "paint" (bottom) were sprayed with aqueous suspensions of Staphylococcus aureus cells, and then incubated. Some 200 bacterial colonies are seen on the unprotected slide—and only 4 on the protected one.

Staphylococcus aureus is described by the CDC as a "superbug" that is resistant to many types of antibiotics. Studies have shown that it can survive for weeks even on hard surfaces.

Klibanov writes:

Our recent studies have resulted in a new, “non-release” strategy for rendering common materials (plastics, glass, textiles) permanently microbicidal. This strategy, involving covalent attachment of certain long, moderately hydrophobic polycations to material surfaces, has been proven to be very effective against a variety of pathogenic bacteria and fungi, both airborne and waterborne. This work continues along with a quest for creating material coatings with anti-viral and anti-sporal activities.

Klibanov and his colleagues found that the prickly polymer worked on bacteria; they tested it with the smaller flu virus and found the same effects. They applied droplets of a flu solution to glass slips painted with the polymer. After a few minutes' exposure, they were unable to recover any active virus from the samples, meaning the coating reduced the pathogen's abundance by at least a factor of 10,000.

How does it work? In the case of bacteria, the polymer seems to gouge holes in a microbe's cell wall and spilling out its contents. The polymer molecules stay rigid because they are all positively charged and repel each other; they are like strands of hair standing on end from a static charge. The spikes have sufficiently few charges, however, that they can breach bacterial walls, which repel strongly charged molecules. The polymer probably neutralizes flu because the virus has an envelope around it suitable for spearing, Klibanov says.

Here are some other inventions that work on small organisms:

From Scientific American via MedGadget; read more about Alexander Klibanov.

Scroll down for more stories in the same category. (Story submitted 11/16/2006)

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