Science Fiction Dictionary
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

 

Neural Net Discovers Antibiotic

A deep neural net algorithm discovered a new antibiotic that displays bactericidal activity against a wide phylogenetic spectrum of pathogens.


(Machine Learning in Antibiotic Discovery)

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity.

We performed predictions on multiple chemical libraries and discovered a molecule from the Drug Repurposing Hub—halicin—that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens including Mycobacterium tuberculosis and carbapenem-resistant Enterobacteriaceae. Halicin also effectively treated Clostridioides difficile and pan-resistant Acinetobacter baumannii infections in murine models.

Additionally, from a discrete set of 23 empirically tested predictions from >107 million molecules curated from the ZINC15 database, our model identified eight antibacterial compounds that are structurally distant from known antibiotics. This work highlights the utility of deep learning approaches to expand our antibiotic arsenal through the discovery of structurally distinct antibacterial molecules.

As far as I know, the earliest mention of a computer able to generate new science is the Total Environmental and Mental Simulator from John M. Faucette's 1968 novel Crown of Infinity.

...A computer that could simulate or duplicate the mental processes of any actual or artificial being, and through simulated total environmental stimuli create a situation of maximum stress upon that entity... No matter how much in intelligence potential Master or ally had, the TEMS always came up with a simulated being that was superior...

... instantly the TEMS was creating and destroying entire systems of logic and mathematics, creating and discarding scores of new sciences.

Via A Deep Learning Approach to Antibiotic Discovery by Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Tommi S. Jaakkola, Regina Barzilay and James J. Collins .

Scroll down for more stories in the same category. (Story submitted 2/5/2020)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Artificial Intelligence ")

Pathways Language Model (PaLM) Is No Joke
'Electronic differentiation of the grotesque, as it says in the specifications - in man, a sense of humor.' - William Tenn, 1951.

Should We Train AIs To Imagine A Future Of Horrific Disasters
'LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN TO LIVE.' - Harlan Ellison, 1967.

AI Employment Decision Software Reconsidered By California Lawmakers
'They had screwed up and been blacklisted by Manna. They were back living with their parents or sleeping on the sofa with a friend.' - Marshall Brain, 2002.

Back In The Office? Relearn To Smile
'I must, therefore, overrule your authority, since you are not in any condition to exercise it intelligently.' - Arthur C. Clarke, 1968.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

Science Fiction Timeline
1600-1899
1900-1939
1940's   1950's
1960's   1970's
1980's   1990's
2000's   2010's

Current News

Lonestar Offers Lunar Storage For Ultimate In Security
'Scarif, the off-site backup of all the secret knowledge of the Empire

Envisioning Starship Earth Travel - In 1930 By Max Valier
'Why must we travel ever faster in a seemingly insatiable desire to conquer space and time?'

Man's Marriage To Hologram Ruined By Software Glitch
Till 'NETWORK ERROR' do us part.

Carbon Robotics: War Of The Worlds As A Metaphor For Weed Control
'It was as if some invisible jet impinged upon them and flashed into white flame.'

Pathways Language Model (PaLM) Is No Joke
'Electronic differentiation of the grotesque, as it says in the specifications - in man, a sense of humor.'

MOOSE: Man Out Of Space Easiest or Manned Orbital Operations Safety Equipment
'And as the ball bulleted downward on a screaming slant, it shrank!'

Liquid Lenses Adjust Automatically, Not Quite Dune Binoculars
'Hufhuf oil held in static tension... within a viewing tube...'

Your Martian Dream Home, Made By Fungi
'... it was the cheapest building material known.'

The Dune Ornithopter, Movie And Book
'The wings were at full spread-rest, their delicate metal interleavings extended.'

100X Improvement In DNA Information Storage
'A record that wouldn't get lost and couldn't be destroyed.'

NASA 'Holoports' Doctor Onto Space Station
Star Trek Voyager Emergency Medical Hologram

Should We Train AIs To Imagine A Future Of Horrific Disasters
'LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN TO LIVE.'

Mouth Haptics Invented By Frederik Pohl In 1965, CMU Now Has Prototype
'What he got was indeed a kiss. It was disconcerting. No kissing lips were visible.'

Two Towns Linked By Sculpture Portal In Real Time
'I am the Guardian of Forever.'

3D Printed Robotic Tentacles
'... articulate ropes of steel dangling'

Update: Musk Doubles Down On Optimus Prime Humanoid Robot
'I shall introduce myself. I am R. Daneel Olivaw... I am a robot. Were you not told?'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.