Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Fantastic Voyage Of Self-assembling Peptide Nanofibers
In the 1966 science fiction movie Fantastic Voyage, researchers miniaturize a delivery mechanism and inject it into a human body. In a modern day sequel, Harvard Medical School researchers have used injectable self-assembling peptide nanofibers loaded with the pro-survival factor PDGF-BB to protect rat hearts from injury and subsequent heart failure. Their study will appear in the January 2006 issue of the Journal of Clinical Investigation.
(1966 Fantastic Voyage)
Narrowed or blocked blood vessels are unable to deliver sufficient levels of oxygen to cardiomyocytes, which results in cardiomyocyte death, loss of the middle layer of the heart wall (the myocardium), and ultimately, heart failure. Therefore, therapies that protect cardiomyocytes from death may help prevent heart failure.In the current study, Richard Lee and colleagues show that PDGF-BB has a direct pro-survival effect on cardiomyocytes. The authors went on to design a strategy in which short, self-assembling peptide nanofibers bind this pro-survival growth factor and, following injection into rat myocardium, facilitated prolonged and controlled delivery of PDGF-BB to the infarcted heart for up to 14 days. This strategy protected cardiomyocytes from injury, reduced infarct size, and preserved cardiac function. This effect could not be achieved by injecting nanofibers or PDGF-BB alone.
In a previous paper, Dr. Lee and his team demonstrated that self-assembling peptide nanofibers can be injected, and that the resulting nanofiber microenvironment can be seen.
If you are interested in this topic, you might also be interested in an Artist's View Of Medical Nanorobots. Read more at ZDNet, the press release, and Molecular Cardiology. And thanks to Fred Kiesche for pointing this one out.
Scroll down for more stories in the same category. (Story submitted 12/20/2005)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Medical ")
Bone-Building Drug Evenity Approved
'Compounds devised by the biochemists for the rapid building of bone...' - Edmond Hamilton, 1932.
BrainBridge Concept Transplant Of Human Head Proposed
'Briquet’s head seemed to think that to find and attach a new body to her head was as easy as to fit and sew a new dress.' - Alexander Belaev (1925)
Natural Gait With Prosthetic Connected To Nervous System
'The leg was to function, in a way, as a servo-mechanism operated by Larry’s brain...' - Charles Recour, 1949.
Brain Implant Is Able To Capture Your Inner Dialogue
'So you see, you can hide nothing from me.'
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
Leader-Follower Autonomous Vehicle Technology
'Jason had been guiding the caravan of cars as usual...'
Golf Ball Test Robot Wears Them Out
"The robot solemnly hit a ball against the wall, picked it up and teed it, hit it again, over and again...'
Boring Company Vegas Loop Like Asimov Said
'There was a wall ahead... It was riddled with holes that were the mouths of tunnels.'
Rigid Metallic Clothing From Science Fiction To You
'...support the interior human structure against Jupiter’s pull.'
Is The Seattle Ultrasonics C-200 A Heinlein Vibroblade?
'It ain't a vibroblade. It's steel. Messy.'
Roborock Saros Z70 Is A Robot Vacuum With An Arm
'Anything larger than a BB shot it picked up and placed in a tray...'
A Beautiful Visualization Of Compact Food
'The German chemists have discovered how to supply the needed elements in compact, undiluted form...'
Bone-Building Drug Evenity Approved
'Compounds devised by the biochemists for the rapid building of bone...'
Secret Kill Switch Found In Yutong Buses
'The car faltered as the external command came to brake...'
Inmotion Electric Unicycle In Combat
'It is about the size and shape of a kitchen stool, gyro-stabilized...'
Grok Scores Best In Psychological Tests
'Try to find out how he ticks...'
PaXini Supersensitive Robot Fingers
'My fingers are not that sensitive...'
Congress Considers Automatic Emergency Braking, One Hundred Years Too Late
'The greatest problem of all was the elimination of the human element of braking together with its inevitable time lag.'
The Desert Ship Sailed In Imagination
'Across the ancient sea floor a dozen tall, blue-sailed Martian sand ships floated, like blue smoke.'
The Zapata Air Scooter Would Be Great In A Science Fiction Story
'Betty's slapdash style.'
Thermostabilized Wet Meat Product (NASA Prototype)
There are no orbiting Michelin stars. Yet.
