Fantastic Voyage Of Self-assembling Peptide Nanofibers

In the 1966 science fiction movie Fantastic Voyage, researchers miniaturize a delivery mechanism and inject it into a human body. In a modern day sequel, Harvard Medical School researchers have used injectable self-assembling peptide nanofibers loaded with the pro-survival factor PDGF-BB to protect rat hearts from injury and subsequent heart failure. Their study will appear in the January 2006 issue of the Journal of Clinical Investigation.


(1966 Fantastic Voyage)

Narrowed or blocked blood vessels are unable to deliver sufficient levels of oxygen to cardiomyocytes, which results in cardiomyocyte death, loss of the middle layer of the heart wall (the myocardium), and ultimately, heart failure. Therefore, therapies that protect cardiomyocytes from death may help prevent heart failure.

In the current study, Richard Lee and colleagues show that PDGF-BB has a direct pro-survival effect on cardiomyocytes. The authors went on to design a strategy in which short, self-assembling peptide nanofibers bind this pro-survival growth factor and, following injection into rat myocardium, facilitated prolonged and controlled delivery of PDGF-BB to the infarcted heart for up to 14 days. This strategy protected cardiomyocytes from injury, reduced infarct size, and preserved cardiac function. This effect could not be achieved by injecting nanofibers or PDGF-BB alone.

In a previous paper, Dr. Lee and his team demonstrated that self-assembling peptide nanofibers can be injected, and that the resulting nanofiber microenvironment can be seen.

If you are interested in this topic, you might also be interested in an Artist's View Of Medical Nanorobots. Read more at ZDNet, the press release, and Molecular Cardiology. And thanks to Fred Kiesche for pointing this one out.

Scroll down for more stories in the same category. (Story submitted 12/20/2005)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

MIT Ampli Blocks Build Biomedical Devices
Damn it Spock, I'm a doctor not an engineer!

Handheld Human Skin Printer
It outputs a thin wad of uniflesh.

Retinal Prosthesis Uses Organic Printing Inks
We can rebuild you - well, your eyes, maybe.

New Brain Scanner Lets You Move Around
'In Bob Arctor's living room his thousand dollar custom-quality cephscope crafted by Altec...' - Philip K. Dick, 1977.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Swarm Of Mindless Robots Works Together
'Very tiny pseudo insects that... can unite to form a superordinate system.'

SpotMini Robot Dog, Autonomous And On Sale In 2019
Great, an autonomous slamhound. It is cute, though.

RoboFly Is Laser-Powered, Adorable
Don't swat this fly!

MSG Sphere Las Vegas, ala Star Wars
'The smoky globe, hung in the vault, was shot with colored light...'

Tetraplegics Dominate Avatar Races
Well, just speaking brain-to-computer...

MIT Ampli Blocks Build Biomedical Devices
Damn it Spock, I'm a doctor not an engineer!

UberAIR Asks For Skytaxi Landing Prototypes
You know you want to ride in one.

Boring Tunnel Almost Ready
Your underground future is calling!

Handheld Human Skin Printer
It outputs a thin wad of uniflesh.

Healthy Fast Food Courtesy Of Robot Chefs
'The electric cook was stirring empty nothing in a pan, with a zeal worthy a dozen eggs.'

Mass Production Of In Vitro Meat From One Sample
They're Assimilating Our Culture, That's What They're Doing

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Retinal Prosthesis Uses Organic Printing Inks
We can rebuild you - well, your eyes, maybe.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

Squid-Like Robots Soon To Be 3D Printable
'It was a chemotactic artificial jellyfish designed to slither...'

Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.