Mind-Altering Drugs Administered Deep Into The Brain

Duke University researchers have worked with mice, stress-susceptible animals that appeared depressed or anxious. By inserting drugs deep within the brain, the mice were restored to relatively normal behavior, according to a study appearing in the forthcoming July 20 issue of Neuron.

The team started by precisely placing arrays of 32 electrodes in four brain areas of the mice (see illustration above). Then they recorded brain activity as these mice were subjected to a stressful situation called chronic social defeat.* This allowed the researchers to observe the activity between the prefrontal cortex and three areas of the limbic system that are implicated in major depression...

They then applied engineered molecules called DREADD (Designer Receptors Exclusively Activated by Designer Drug), developed by University of North Carolina at Chapel Hill pharmacologist Bryan Roth, in very tiny amounts (0.5 microliter). A drug that attaches only to that DREADD is then administered to give the researchers control over the circuit.

They found that direct stimulation of PFC-amygdala neural circuitry with DREADDs normalized PFC-dependent limbic synchrony in stress-susceptible animals and restored normal behavior.

In his 2015 novel Killing Titan, Greg Bear writes about cranial amplified programming devices and suits that can settle mood-altering chemicals deep into the brain and the body.

Hey, I'm in a good mood. I'm laughing in my big thick helm, even as painful and intrusive bits of the suit - my suit, my friend! - absorb my sweet flesh the way product eats the station. I'm down with that. I'm down with pain, poison and frozen death. Happy to serve!"

Via KurzweilAI.

Scroll down for more stories in the same category. (Story submitted 6/22/2016)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Bioreactor Helps Legless Frogs Get Their Jump Back
'An alien drug... Used by an insect race... It can repair bones and organs. It can grow new tissue." - Clifford Simak, 1961

Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.' - Arthur C. Clarke, 1963.

You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.' - Frank Herbert, 1972.

First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Soon, Your Tesla Will Follow You Like A Pet
'... follow him as faithfully as a well-trained hound.'

Chinese Watrix Gait Recognition Watching You Always
'... those pesky gait-recognition cameras.'

FlexPai Foldable Phone By Royole
'...A paper thin polycarbon screen unfurled.'

Oh Yes, We're Building The Rotating Tower In Dubai
'Give me an old-fashioned tetragon on a central pivot every time.'

Bioreactor Helps Legless Frogs Get Their Jump Back
'An alien drug... Used by an insect race... It can repair bones and organs. It can grow new tissue."

Xinhua AI Anchor Puts CGI Face To Automated News
'...a congeries of software agents.'

Wirewax Watching You Watch, Adjusting Your Experience
'He adjusted the n, the r and b knobs, and hopefully anticipated a turn for the better...'

LawGeex AI Beats 20 Top Lawyers
'The Law Society has strict rules on the use of pseudo-intelligent software - terrified of putting... its members out of work.'

ROAM Robotics Skiing Exoskeleton
'The real genius in the design is that you don't have to control the suit; you just wear it...'

MIT Headset Lets You Communicate Without Speaking
'The subvocal read nerve signals, letting her enter words by just beginning to will them...'

Exploring Oceans Across The Solar System
'Black liquid flashed past the turbotís infrared eyes.'

SWEEPER Robot Peter Piper Picking Peppers
'... little machines, that went from plant to plant, apparently on caterpillar tracks, cutting off the ripe fruit.'

Oil from Algae - Can It Be Done?
'We dump everything that's waste into the tanks, pump the oil off the top.'

Moving Whole Planets, Revisited
There was a lot of work done on this idea over the years.

Disney Keeps Backups Of Star Wars Franchise Actors
'She is a personality-construct, a congeries of software agents...'

Farming In Space Starts With Mycorrhiza
'The inner leaves were beginning to curl faster than the outer leaves.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.