Epigenetic Memory's On/Off Switch Found
Epigenetics is the study of inheritable changes in gene expression not directly coded in our DNA. It appears that our life experiences can be passed on to our children, and to future generations, by this mechanism.
(From Transgenerational Small RNA Inheritance)
The duration of epigenetic responses underpinning
transgenerational inheritance is determined by an active
mechanism relying on the production of small RNAs
and modulation of RNAi factors, dictating whether ancestral
RNAi responses would be memorized or forgotten.
(credit: Leah Houri-Ze’evi et al./Cell)
“Until now, it has been assumed that a passive dilution or decay governs the inheritance of epigenetic responses,” said Oded Rechavi, PhD, from TAU’s Faculty of Life Sciences and Sagol School of Neuroscience. “But we showed that there is an active process that regulates epigenetic inheritance down through generations.”
The scientists discovered that specific genes, which they named “MOTEK” (Modified Transgenerational Epigenetic Kinetics), were involved in turning epigenetic transmissions on and off.
“We discovered how to manipulate the transgenerational duration of epigenetic inheritance in worms by switching ‘on’ and ‘off’ the small RNAs that worms use to regulate [these] genes,” said Rechavi.*
These switches are controlled by a feedback interaction between gene-regulating small RNAs, which are inheritable, and the MOTEK genes that are required to produce and transmit these small RNAs across generations.
The feedback determines whether epigenetic memory will continue to the progeny or not, and how long each epigenetic response will last.
The first time I read about this idea was in an excellent series of fantasy novels by Barbara Hambly. In her 1982 Darwath trilogy, she writes about how wizards of several thousand years ago succeeded in tying information to the DNA of selected individuals. In the story, several people from 1980's California find themselves transported across the Void to another planet and the Realm of Darwath. They face a deadly species of queerly magical beings - the Dark - who destroyed civilization thousands of years ago. Everything that was made of paper (like books and records) were burned to stave off attacks by the Dark. Tying memories to a few suitable bloodlines was the only way to preserve a record of that period that would endure.
"We have all talked of the heritable memories of the House of Dare," she went on... maybe the old wizards, the engineers who raised the Keep, knew that records do get lost, especially when, as you said, fire is the principal weapon."
Gil's finger stabbed out like a sword. "They tied the memory to the bloodline and that was their record! A record that wouldn't get lost and couldn't be destroyed."
Scroll down for more stories in the same category. (Story submitted 3/29/2016)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
DNA May Contain Malware
'You were told to embed the logical pathogen.' - A. Reynolds and S. Baxter, 2016.
GMO Houseplant Cleans Your Air
Removes compounds too small to be captured by a HEPA filter.
Oil from Algae - Can It Be Done?
'We dump everything that's waste into the tanks, pump the oil off the top.' - Hal Clement, 1950.
Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
BrainEx Restores Some Activity To Severed Pig Head
'... they placed the brain in a special solution, having all the properties of Nursing the brain cells.'
Yes, But Do Astrobees Have Lasers For Lightsaber Training?
'... Ancient weapons are no match for a good blaster at your side, kid.'
'Young Razorbacks Before Their Katanas Grow In'
'Twin robotic arms with gleaming three-foot sword blades unfolded from the forward hydraulic assemblies...'
A New Way To Run Into Things
'He made an adjustment, pointed the tube at the wall beside Etzwane, and projected a cone of light.'
'Metallic Wood' Strong Like Titanium, Floats In Water
'A metal... light as cork and stronger than steel...'
Seabreacher, H.G. Winter's 1939 Torpoon
'Ken lay full-length in the padded body compartment, his feet resting on the controlling bars of the directional planes, hands on the torpoon's engine levers.'
Abundant Robotics Autonomous Apple Harvester Robot
'... little machines, that went from plant to plant... cutting off the ripe fruit.'
Charging An Electric Car In 2019 (Video), 1912 (Photo) And 1894 (Fiction)
'Recharge the batteries... in almost every town and village...'
Japan Uses Explosives On Asteroid
'...a tiny, rocket-powered projectile, drove towards the mysterious bulk. It hit, exploding into a cloud of incandescent vapour.'
Get Your Speeder Flying Motorcycle From Jetpack Aviation
'The flycycles were miracles of compact design.'
FLIR Black Hornet 3 Palm-sized Drone
These drones can provide situational awareness beyond visual line-of-sight capability.
Dockworkers Protest Driverless Trucks
'It resembled conventional human-operated transportation vehicles, but with one exception -- there was no driver's cabin.'
Flying Car Concept By Kash Sirinanda
'Each one consists of a hub with many tiny spokes... On the end is a squat foot, rubber tread on the bottom...'
Unfurl The Future! Huawei Mate X versus Galaxy Fold
'A paper thin polycarbon screen unfurled silently from the top of the unit and immediately grew rigid.'
Amazon Echo And Google Home Should Have Morality Software
'The Dwoskin Morality Rating-Computer could 'spot the slightest tendency to deviation' from the social norm...'
China Building Robot Wives
'Want a life-companion, a pleasant one?'
More SF in the News Stories
More Beyond Technovelgy science news stories