The Secret of Longevity?
Apparently, genes, according to scientists at Stanford University and the University of Bologna.
Genetic studies so far have only identified a single gene (APOE, known to be involved in Alzheimer’s disease) that is different in centenarians versus normal agers.
To find the additional longevity genes, the authors first developed a new statistical method called informed GWAS (genome-wide association studies), which uses knowledge from 14 diseases to narrow down the search genes associated with longevity.
Using iGWAS, the scientists found eight SNPs (single nucleotide polymorphisms — molecular variations at different locations on the gene) that are significant for the centenarians they studied, and they were able to validate four of these in replication studies of long-lived subjects.
The four “longevity loci” (gene locations) along with the APOE gene may provide clues about physiological mechanisms for successful aging. These loci are known to be involved in various processes including cell senescence, autoimmunity, and cell signaling, and also with Alzheimer’s disease.
Future work may lead to a better understanding of how these genes promote successful aging and could identify additional longevity genes by recruiting more centenarians for analysis.
Robert Heinlein came to pretty much the same conclusion in his 1941 classic Methuselah's Children, in which he introduces his Howard Families, the long-lived.
"The first offspring resulting from unions assisted by the Howard Foundation were born in 1875.
They aroused no comment, for they were in no way remarkable. The Foundation was an openlychartered
On March 17, 1874, Ira Johnson, medical student, sat in the law offices of Deems, Wingate, Alden,
& Deems and listened to an unusual proposition. At last he interrupted the senior partner. "Just a
moment! Do I understand that you are trying to hire me to marry one of these women?"
The lawyer looked shocked. "Please, Mr. Johnson. Not at all"
"Well, it certainly sounded like it."
"No, no, such a contract would be void, against public policy. We are simply informing you, as
administrators of a trust, that should it come about that you do marry one of the young ladies on this list
it would then be our pleasant duty to endow each child of such a union according to the scale here set
forth. But there would be no Contract with us involved, nor is there any 'proposition' being made to youand
we certainly do not urge any course of action on you. We are simply informing you of certain facts."
Ira Johnson scowled and shuffled his feet. "What's it all about? Why?"
"That is the business of the Foundation. One might put it that we approve of your grandparents."
"Have you discussed me with them?" Johnson said sharply.
He felt no affection for his grandparents. A tight-fisted foursome-if any one of them had had the
grace to die at a reasonable age he would not now be worried about money enough to finish medical
Scroll down for more stories in the same category. (Story submitted 12/21/2015)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
iFlytek Doctor Robot First To Pass Medical Exams
No problem, we'll just use the autodoc.
Watch What People Are Seeing Via Brain Scanning
'had managed to see through the other man's eyes as the other man, all unaware, washed their Zis limousine sixteen hundred meters away...' - Cordwainer Smith, 1958.
PRIMA Bionic Vision Restoration
'The VISOR... was a medical device used in the Federation to aid patients who have suffered loss of eyesight...'
Targeted Neuroplasticity Training For 'Downloading Skills'
'I know kung-fu.'
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
A 'Genuine Nanorobotic Production Factory'
'Microscopic machinery, smaller than ants, smaller than pins, working energetically, purposefully - constructing something...'
Neuromorphic Computer Offers Non-von Neumann Architecture
Fires faster than brain at 1/10K energy.
Evorus Your Crowd-Powered Conversational Assistant
'...the DS [Daily Schedule] was suddenly transformed into a valued confidante.'
Mealworms Food Of The Future
Get your grubs on.
Alibaba's AI May Read Better Than You
'Mike ... could accept other languages and was doing technical translating - and reading endlessly.'
Musk's Boring Flamethrower
'Skeletons in tatters. Burned by a flesh gun'
Humanity Star LEO Advertisement?
'Everyone has noticed those enormous advertisements...'
Nissan ProPILOT Slippers Are Self-Parking, Autonomous
Beyond science and fiction.
Atomristors - Atomic Memristors - Using Thin Nanomaterials
'I could almost feel those little tunnel junction neuristors working, forming their own interconnections as I operated it.'
Bigelow Prepares Inflatable Lunar Hotel
'Suddenly, hitherto unheard-of sums of money became available for investment in civilian orbital stations.'
Drunk Driver Of Tesla Claims Autopilot Was In Charge
'Mr. Garden, you are in no condition to drive.'
Medical Exoskeleton From Cyberdyne Gets FDA Approval
It's been a long road for HAL-5; I started writing about it in 2005.
Fungi-Infused Concrete Repairs Itself
'I noticed that curious mottled knots were forming, indicating where the room had been strained and healed faultily.'
Shiftwear Display Shoes
'He unlaced her shoe and glanced at its readout.'
NASA SEXTANT First With X-Ray Nav In Space
'You need at least four beacons for an accurate fix.'
GM Introduces Cruise AV With No Steering Wheel
'How about the steering wheel?' ... 'I do not need one.'
More SF in the News Stories
More Beyond Technovelgy science news stories