The Secret of Longevity?

Apparently, genes, according to scientists at Stanford University and the University of Bologna.

Genetic studies so far have only identified a single gene (APOE, known to be involved in Alzheimer’s disease) that is different in centenarians versus normal agers.

To find the additional longevity genes, the authors first developed a new statistical method called informed GWAS (genome-wide association studies), which uses knowledge from 14 diseases to narrow down the search genes associated with longevity.

Using iGWAS, the scientists found eight SNPs (single nucleotide polymorphisms — molecular variations at different locations on the gene) that are significant for the centenarians they studied, and they were able to validate four of these in replication studies of long-lived subjects.

The four “longevity loci” (gene locations) along with the APOE gene may provide clues about physiological mechanisms for successful aging. These loci are known to be involved in various processes including cell senescence, autoimmunity, and cell signaling, and also with Alzheimer’s disease.

Future work may lead to a better understanding of how these genes promote successful aging and could identify additional longevity genes by recruiting more centenarians for analysis.

Robert Heinlein came to pretty much the same conclusion in his 1941 classic Methuselah's Children, in which he introduces his Howard Families, the long-lived.

"The first offspring resulting from unions assisted by the Howard Foundation were born in 1875. They aroused no comment, for they were in no way remarkable. The Foundation was an openlychartered non-profit corporation--"

On March 17, 1874, Ira Johnson, medical student, sat in the law offices of Deems, Wingate, Alden, & Deems and listened to an unusual proposition. At last he interrupted the senior partner. "Just a moment! Do I understand that you are trying to hire me to marry one of these women?"
The lawyer looked shocked. "Please, Mr. Johnson. Not at all"
"Well, it certainly sounded like it."
"No, no, such a contract would be void, against public policy. We are simply informing you, as administrators of a trust, that should it come about that you do marry one of the young ladies on this list it would then be our pleasant duty to endow each child of such a union according to the scale here set forth. But there would be no Contract with us involved, nor is there any 'proposition' being made to youand we certainly do not urge any course of action on you. We are simply informing you of certain facts."
Ira Johnson scowled and shuffled his feet. "What's it all about? Why?"
"That is the business of the Foundation. One might put it that we approve of your grandparents."
"Have you discussed me with them?" Johnson said sharply.
He felt no affection for his grandparents. A tight-fisted foursome-if any one of them had had the grace to die at a reasonable age he would not now be worried about money enough to finish medical school.

Via KurzweilAI.

Scroll down for more stories in the same category. (Story submitted 12/21/2015)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Drug Creates Real Melanin Tan
I've used them all my life...

Medical Drones Hover Like Angels Near You
'The death-reversal equipment is on its way...'- Frederk Pohl, 1965.

Vaccine Blocks Heroin High
'You're biochemically incapable of getting off...' - William Gibson, 1985.

Ambrosia Start-Up Offers New Blood For Old 'Caper'
'It consists largely in replacing the entire blood tissue in an old person with new, young blood...' - Robert Heinlein, 1941.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

TALOS Exoskeleton Development Proceeding
'Suited up, you look like a big steel gorilla...'

Autonomous Robots Navigate Like Rats
'Out of warrens in the wall, tiny robot mice darted.'

SINTEF Robot Cleans Solar Panels
'The window cleaners, with large padded feet...'

Pangorin Restaurant Service Robots
What'll you have? Jawa juice?

Drug Creates Real Melanin Tan
I've used them all my life...

Medical Drones Hover Like Angels Near You
'The death-reversal equipment is on its way...'

SkEye Amazing Israeli Gigapixel Drone
'An eye that could not only see, but fly...'

How Rude! DARPA Wants Robots To Behave More Like Threepio
'Do I know protocol? Why, it's my primary function.'

'Liquid Light' Flows Around Corners
Light as a superfluid.

Unrolling The Filmy Materials Of Space Tech
'When unfolded and unrolled... it became a tough, gleaming film.'

Buddy Companion Robot Your Bulbous Friend
'Nanny was built in the shape of a sphere, a large metal sphere, flattened on the bottom...'

Poli-X1 Prototype Bee Pollinator
Is there anything drones can't do?

Bake in Space Bake-Off... In Space!
'A joyous condition commenced for the cook in the electric kitchen...'

DeepMind AI Baffled By Homer Simpson, Needs Human Help
'Whenever a robot finds something it can't identify straight off...'

Does Earth's Middle Mantle Hold Oceans Of Water?
Al Gore, you have no idea.

Vaccine Blocks Heroin High
'You're biochemically incapable of getting off...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.