Mini-Livers Made By 3D Printer

Tiny livers have been printed in the lab by Organovo in San Diego, California. These mini-livers are just four millimeters across and half a millimeter deep, but they perform most of the functions of real livers.


(Organovo 3D prints mini-livers)

To create them, a printer builds up about 20 layers of hepatocytes and stellate cells two major types of liver cell. Crucially, it also adds cells from the lining of blood vessels. These form a delicate mesh of channels that supply the liver cells with nutrients and oxygen, allowing the tissue to live for five days or longer. The cells come from spare tissue removed in operations and biopsies.

Existing liver assays, based on single or double layers of cells, only last two days and don't have the same range of functions as the micro-discs.

The realistic structure and functioning of the mini-livers make them good predictors of the toxicity of drugs and other substances. They produce albumin, the liver protein that bulks up blood and ferries hormones, salts and drugs throughout the body. They also make cholesterol, which carries fat in the bloodstream, and produce major detoxification enzymes, called cytochrome P450s, that metabolise drugs in the liver.

Artificially grown livers for transplantation was one of the issues discussed by science fiction writer Larry Niven in his 1968 novel A Gift from Earth:

...For a while your colonists will have to come up to the Hospital to get treatment with the ramrobot symbiots, but eventually we can build culture tanks in Gamma and Delta and Eta."
(Read more about Larry Niven's artificially grown organs)

Via New Scientist.

Scroll down for more stories in the same category. (Story submitted 4/29/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 7 )

Related News Stories - (" Medical ")

Injectable Magnetic Fluid Slows Bleeding, Aids Magneto
'There's something different about you.'

Vascularized Human Skin 3D Printed
Hey Fishboy! Three days and you're out!

China Accused Of Harvesting Organs From Unwanted Groups
'The death penalty was his immortality, and he would vote the death penalty for any crime at all.' Larry Niven, 1967.

Robothread Robotic Worms Crawling Through Your Brain
Perfect for clot-busting in the human brain. No Raquel Welch and no lasers, though.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Extremophile Microbe Loves Space Rocks
'... designed for rooting in the metal make-up of the asteroids for vital elements.'

Magic Mushroom Nose Spray From Silo Wellness
'I don't need help... that's not my diagnosis!'

CAV-X Supercavitating Ammo Deadly Underwater
'...in the midst of this fluid, which is very dense compared with the atmosphere, shots could not go far.'

Space Domes Over-rated? Science Fiction Authors Have Answers
'This was to be roofed over, sealed, and an atmosphere provided...'

Injectable Magnetic Fluid Slows Bleeding, Aids Magneto
'There's something different about you.'

Autonomous Wheelchairs Improve Airport Mobility
'Noiselessly, on rubber-tired wheels, they journeyed down the long aisles...'

HVSD, Kitty Hawk's Electric Plane
Very quiet commuter plane offers VTOL service.

Frictionless Toilet Could Save 140 Billion Liters Of Water
'The bowl was a frictionless surface...'

Viisights AI Hones Video Surveillance
'The math boys worked it out...'

Cybertruck The Solar-Powered Steel Tortoise
'It drew its power from... sunpower screens on its low curved roof.'

Road Noise Charges Electric Cars With Peugeot Piezoelectric Billboard
''... major cities of Earth have free electrical power conveniently processed from their own noise.'

Unsinkable Metal Latest Gates Obsession
'A metal... light as cork.'

M-Blocks 2.0 Self-Assembling Robots
'Faster the cubes moved...'

NASA 'Broomstick' Recalls SciFi Ideas
'The appearance was enough like a giant witch's broom to justify the nickname.'

Orbital Display's Low Earth Orbit Advertisements
'A vast circle of scarlet stars came up into the greenish desert dusk.'

Neuromorphic Computing Hardare
'He had constructed an organ, a brain, of metal, entirely inorganic and lifeless...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.