Mini-Livers Made By 3D Printer

Tiny livers have been printed in the lab by Organovo in San Diego, California. These mini-livers are just four millimeters across and half a millimeter deep, but they perform most of the functions of real livers.


(Organovo 3D prints mini-livers)

To create them, a printer builds up about 20 layers of hepatocytes and stellate cells two major types of liver cell. Crucially, it also adds cells from the lining of blood vessels. These form a delicate mesh of channels that supply the liver cells with nutrients and oxygen, allowing the tissue to live for five days or longer. The cells come from spare tissue removed in operations and biopsies.

Existing liver assays, based on single or double layers of cells, only last two days and don't have the same range of functions as the micro-discs.

The realistic structure and functioning of the mini-livers make them good predictors of the toxicity of drugs and other substances. They produce albumin, the liver protein that bulks up blood and ferries hormones, salts and drugs throughout the body. They also make cholesterol, which carries fat in the bloodstream, and produce major detoxification enzymes, called cytochrome P450s, that metabolise drugs in the liver.

Artificially grown livers for transplantation was one of the issues discussed by science fiction writer Larry Niven in his 1968 novel A Gift from Earth:

...For a while your colonists will have to come up to the Hospital to get treatment with the ramrobot symbiots, but eventually we can build culture tanks in Gamma and Delta and Eta."
(Read more about Larry Niven's artificially grown organs)

Via New Scientist.

Scroll down for more stories in the same category. (Story submitted 4/29/2013)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 7 )

Related News Stories - (" Medical ")

Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.' - Arthur C. Clarke, 1963.

You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.' - Frank Herbert, 1972.

First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.

Nanorobots Roam Your Bloodstream, Cleaning It
Too bad they won't have lasers, though...

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Sleeep PRO Earplug For Maximum Rest
'Merton... placed the electrodes of the sleep-inducer on his forehead.'

Inspired By Japan, Nap Pods For Hajj
It's always a good time for a nap.

Amphibio 3D Printed Gill Shirt
'... we can descend and live down there at one of those year-round aquatic resorts.'

How Do You Put An Asteroid Into Earth Orbit? Carefully!
'...she would have to be coaxed by another series of pats into a circular orbit.'

PD Aerospace Space Plane By 2023
'The sleek, tapered space shuttle lay immobile upon the private landing field...'

Foldimate Folds Your Clothes Perfectly
Look ma, my room is clean! I can hear you now.

Robots Help People Get Dressed, As Predicted In 1931
Yes, people of the future, robots will dress you.

International Space Station Leak Plugged - With Finger
'These tag-alongs search out stray leaks.'

Robot Snake Flies, Fights Fires
Just a prototype, but still amazing.

IPAL Chinese Robot Babysitter
'But Nanny is different...'

ZKZM-500 LASER Assault Rifle
'The Iranian reached back into the locker and got a pair of laserifles.'

LA Subway Scanner, As Seen In 'Total Recall'
'I'm afraid to tell you this Mr. Quaid, but you have suffered a schizoed embolism...'

Sion Electric Car Covered With Solar Panels
'It drew its power from six square yards of sunpower screens on its low curved roof.'

PAL-V Liberty Flying Helicopter Car
'...lifted themselves to skimming flight upon whirling helicopters."

Space Drones - UK's Effective Space To Launch Rocket Tugs
'Twenty rocket tugs towed it from its Earth hangar out into space.'

DIY Autonomous Robot Detects Trash
'The search-bug detached itself and rolled forward.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.