The Most Complex Synthetic Biology Circuit

MIT researchers have created what is being called the most complex synthetic biology circuit ever built.

Synthetic biologists design cellular circuits that can perform new functions, such as sensing environmental conditions, using genes as interchangeable parts. However, most of the circuits designed so far have been limited by the difficulty in assembling genetic components that donít interfere with each other.


(4-input AND gate)

Unlike electronic circuits on a silicon chip, biological circuits inside a cell cannot be physically isolated from one another. ďThe cell is sort of a burrito. It has everything mixed together,Ē says Christopher Voigt, an associate professor of biological engineering at MIT.

Because all the cellular machinery for reading genes and synthesizing proteins is jumbled together, researchers have to be careful that proteins that control one part of their synthetic circuit donít hinder other parts of the circuit.

Voigt and his students have now developed circuit components that donít interfere with one another, allowing them to produce the most complex synthetic circuit ever built. The circuit, described in the Oct. 7 issue of Nature, integrates four sensors for different molecules. Such circuits could be used in cells to precisely monitor their environments and respond appropriately.

ďItís incredibly complex, stitching together all these pieces,Ē says Voigt, who is co-director of the Synthetic Biology Center at MIT. Larger circuits would require computer programs that Voigt and his students are now developing, which should allow them to combine hundreds of circuits in new and useful ways.

The pathway consists of three components: an activator, a promoter and a chaperone. A promoter is a region of DNA where proteins bind to initiate transcription of a gene. An activator is one such protein. Some activators also require a chaperone protein before they can bind to DNA to initiate transcription.

Fans of science fiction writer Greg Bear recall the living "biologics" from his 1984 novel Blood Music:

Why limit oneself to silicon and protein and biochips a hundreth of a millimeter wide, when in almost every living cell there was already a functioning computer with a huge memory? A mammallian cell had a DNA complement of several million base pairs, each acting as a piece of information. What was reproduction, after all, but a compterized biological process of enormous complexity and reliability? The earliest biologic strings had been inserted into E. coli bacteria as circular plasmids...
(Read more about Greg Bear's biologics)

Via Kurzweil AI and MIT.

Scroll down for more stories in the same category. (Story submitted 10/8/2012)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Biology ")

GMO Houseplant Cleans Your Air
Removes compounds too small to be captured by a HEPA filter.

Oil from Algae - Can It Be Done?
'We dump everything that's waste into the tanks, pump the oil off the top.' - Hal Clement, 1950.

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Spicy Tomatoes Created With Genetic Engineering
How about mashed potatoes and brown gravy?

Driverless Hotel Rooms Predicted In 1828
'Did you never see a moving house before?'

Yandex Self-Driving Taxi Is Very Smooth
'The big car was slowing down, its computer brain sensing an exit ahead.'

Shrimp Actually Made Of Algae Is A New Wave Food
Bring in that crop algae.

Cosplay Style Wings Could Work On Moon
'They're lovely! - titanalloy struts as light and strong as bird-bones...'

Tesla Model 3 Has Outside Speaker Grille
Robert Heinlein does it again.

Arizona Luddites Attack Self-Driving Vehicles
'Trucks don't drive by themselves...' Or do they?

Organaut! Russians 3D Print Living Tissue In Space
'For a while your colonists will have to come up [to orbit] to the Hospital...'

WINE Spacecraft To Extract Water From Asteroids
'Yes, strangely enough there was still sufficient water beneath the surface of Vesta.'

Japanese Swordsmiths Take On Asteroids
'... a tiny, rocket-powered projectile, drove towards the mysterious bulk.'

Saturn's Rings To Vanish, Let's Mine Them While We Can
'...the valuable shards of what had once been satellites.'

Humans Could Take Up A LOT Less Space
We'd have a lot more room for gardening...

Implosion Fabrication Shrinks 3D Objects To Nanoscale
'Carter had watched miniaturization a hundred times...'

GMO Houseplant Cleans Your Air
Removes compounds too small to be captured by a HEPA filter.

Nova Meat Can 3D Print Your Dinner
Printing out chicken nuggets.

MIT Scientists Create 'Peek-a-Boo Prober' From Jetsons
Well, George, it's the latest thing.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.