PKR-Inhibiting Drugs May Boost Memory

Suppression of the molecule PKR (the double-stranded RNA-activated protein kinase) may help in the formation of long-term memory in the brain, according to researchers at the Baylor College of Medicine.


( Suppression of the PKR molecule
in mutant mice (right) enhances learning
and memory by lowering GABA release,
compared to the process in "wild type"
(normal) mice (left))

"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.

The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform’s location. By contrast, mice lacking PKR learned the task after only one training session.

Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor - a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."

"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR". Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.

SF fans have long memories on this topic. In his 1985 story Stone Lives, Paul Di Filippo wrote about a drug called mnemotropin:

One day Stone notices a pill on his lunch tray. He asks June its nature.

"It's a mnemotropin - promotes the coding of long-term memories," she replies. "I thought it might help you..."
(Read more about mnemotropin)

From Baylor College of Medicine via Kurzweil AI.

Scroll down for more stories in the same category. (Story submitted 12/18/2011)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Biology ")

DNA May Contain Malware
'You were told to embed the logical pathogen.' - A. Reynolds and S. Baxter, 2016.

GMO Houseplant Cleans Your Air
Removes compounds too small to be captured by a HEPA filter.

Oil from Algae - Can It Be Done?
'We dump everything that's waste into the tanks, pump the oil off the top.' - Hal Clement, 1950.

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Unfurl The Future! Huawei Mate X versus Galaxy Fold
'A paper thin polycarbon screen unfurled silently from the top of the unit and immediately grew rigid.'

Amazon Echo And Google Home Should Have Morality Software
'The Dwoskin Morality Rating-Computer could 'spot the slightest tendency to deviation' from the social norm...'

China Building Robot Wives
'Want a life-companion, a pleasant one?'

China Social Credit System Like State-Run Whuffie
'At least there was no mandatory Whuffie check on the monorail platform...'

Project Soli Radar Gesture Chip Now FCC Approved
'He waved his hand and the circuit switched abruptly.'

Stan, Robot Valet, Will Drag Your Car Away
'He activated the grapple tracks. '

Jibo Home Robot Says Goodbye, Is Killswitched
'It resembles an oyster....'

Johns Hopkins Says Asteroid Deflection Will Be Difficult
'This obelisk is one huge deflector mechanism...'

Fabric Automatically Cools Or Insulates Based On Environment
'...a high-efficiency filter and heat-exchange system.'

Deepfakes From OpenAI GPT-2 Algorithm
'How can you compete with an IBM heavy-duty logomatic analogue?'

John Deere Self-Driving Tractor
'The huge plow... seemed to shake itself - and began to move back southward.'

North Focals Smart Glasses Provide Augmented Reality In Style
'The world ... is drenched in unfamiliar information all the way to the horizon.'

Tesla Driver Caught Napping Behind The Wheel
'Mary Risling settled back for a little nap...'

Hayabusa 2 To Begin Asteroid Mining
'We must dig down, and then doubtless we shall find the metal.'

Ionocraft Drone Powered By Electrohydrodynamic Thrust
'He saw one hiss by him as he rounded the corner, trailing a short whip antenna...'

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.