PKR-Inhibiting Drugs May Boost Memory
Suppression of the molecule PKR (the double-stranded RNA-activated protein kinase) may help in the formation of long-term memory in the brain, according to researchers at the Baylor College of Medicine.
Suppression of the PKR molecule
in mutant mice (right) enhances learning
and memory by lowering GABA release,
compared to the process in "wild type"
(normal) mice (left))
"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.
The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform’s location. By contrast, mice lacking PKR learned the task after only one training session.
Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor - a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."
"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR". Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.
SF fans have long memories on this topic. In his 1985 story Stone Lives, Paul Di Filippo wrote about a drug called mnemotropin:
One day Stone notices a pill on his lunch tray. He asks June its nature.
"It's a mnemotropin - promotes the coding of long-term memories," she replies. "I thought it might help you..."
(Read more about mnemotropin)
From Baylor College of Medicine via Kurzweil AI.
Scroll down for more stories in the same category. (Story submitted 12/18/2011)
Follow this kind of news @Technovelgy.
| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
you like to contribute a story tip?
Get the URL of the story, and the related sf author, and add
Comment/Join discussion ( 0 )
Related News Stories -
Hackers Insert Malware Into DNA
'They tied the memory to the bloodline and that was their record!' -
Worms Eat Plastic Now
'Slowly and inexorably, the rate of dissolution increased...' - Davis/Pedlar, 1971.
Mini-Brains In A Dish
'Cultured brains on a slab.' - Peter Watts, 1999.
NASA's Prototype Lunar Greenhouse For Mars And Moon
'In contrast to the airless desolation outside, the interior of this five-acre greenhouse was the one most desirable place to be.' - Raymond Z. Gallun, 1951.
Technovelgy (that's tech-novel-gee!)
is devoted to the creative science inventions and ideas of sf authors. Look for
the Invention Category that interests
you, the Glossary, the Invention
Timeline, or see what's New.
3D Printed Artificial Muscles Are Stronger Than Yours
Bots don't need to work out.
Fog Computing (AKA Edge Computing) Ad Hoc Networks
'The tiny devices chirped their impulse codes at one another...'
Dubai Scorpion Police Hoverbike Ready To Pull Young Kirk Over
'Is there a problem, officer?'
HEXA Robotic Help For Plants
Then some unknown race had chanced upon the dreamers and decided to "help them out."
Korean Tesla Model S Video 'Excelsior' Is Indeed Our Motto
'Improving man by bringing him close to Nature, while they combine the sensations of coasting with the interest of seeing the country well...'
DIY Robot Shoots You In The Face
'...there were automatic guns that fired ligamine darts.'
A Bayesian Approach to Safe Imitation Learning For AIs and Robots
Um, how about that pension for the humans who serve as the models for robot behavior?
Qoobo Headless Robotic Therapy Cat Was Anne McCaffrey's Idea
'...used as surrogates in intense dependency cases.'
Autonomous Cars Talk To Each Other At MCity
'My cars talk to one another.'
PUFFER Robots - From Philip K DIck's Second Variety?
'Across the ground something small and metallic came, flashing in the dull sunlight of midday.'
Russian Space Garden
'We saw the gardens, flooded with artificial sunlight...'
Targeted Neuroplasticity Training For 'Downloading Skills'
'I know kung-fu.'
U of M's MCity To Feature Asimov's Automatobuses
Should you turn autonomous buses off?
Crazyflie Drone Swarm Technology
'...Programmed to hang in space in a hexagonal grid pattern.'
Our GodBot, Who Art In Cyberspace
Vaal hungers! We must serve him.
easyJet Short-Haul Electric Jets
Have a little faith, will you? They're working on it.
More SF in the News Stories
More Beyond Technovelgy science news stories