PKR-Inhibiting Drugs May Boost Memory

Suppression of the molecule PKR (the double-stranded RNA-activated protein kinase) may help in the formation of long-term memory in the brain, according to researchers at the Baylor College of Medicine.


( Suppression of the PKR molecule
in mutant mice (right) enhances learning
and memory by lowering GABA release,
compared to the process in "wild type"
(normal) mice (left))

"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.

The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform’s location. By contrast, mice lacking PKR learned the task after only one training session.

Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor - a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."

"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR". Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.

SF fans have long memories on this topic. In his 1985 story Stone Lives, Paul Di Filippo wrote about a drug called mnemotropin:

One day Stone notices a pill on his lunch tray. He asks June its nature.

"It's a mnemotropin - promotes the coding of long-term memories," she replies. "I thought it might help you..."
(Read more about mnemotropin)

From Baylor College of Medicine via Kurzweil AI.

Scroll down for more stories in the same category. (Story submitted 12/18/2011)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Biology ")

Mushroom Coffin Returns You To Nature, Naturally
'She touched the leaf. She was wanted.' - Philip K Dick, 1954.

Mechanical Milking Of Microalgae For Fuel Production
'They call 'em culture tanks. They have bugs -- germs -- growing in them.' - Hal Clement, 1950.

Fetal Lamb Rests In Artificial Womb
'... stewing warm on their cushion of peritoneum and gorged with blood-surrogate and hormones, the foetuses grew and grew...' - Aldous Huxley, 1932.

Bring Back Extinct Animals! Sort of.
'The worldwide network of genetic arks had a surfeit of pachyderms...' - David Brin, 1990

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Jet-Powered Flying Suits Tested By Navy
'With his motor in operation, he moves like a diver, head foremost...'

Pub Installs Electrified Fence Around Bar
'I start twelve immensely strong wires--naked, not insulated --from a big dynamo...'

What Does A Tesla Full Self-Driving Car See?
'All objects within my panoramic gaze trembled and vibrated like quick motion pictures...'

BioVYZR Is Ready, Anti-Covid19 PAPR Lovers
'Some clad in the insulated space-suits, with their transparent glassite helmets.'

Tesla Will Have Metal Gear Snake Autocoupler, Musk Confirms
'Its motion was so swift, complex, and perfect that at first I did not see it as a machine, in spite of its metallic glitter.'

Starlink Satellites Leading Edge On-Orbit Debris Mitigation
Propulsion-assisted orbital decay, brought to you by SpaceX.

Healight Ultraviolet Endotracheal Device Has Covid-19 Treatment Potential
'He applied the tip of the instrument to the interior of the wound...'

Parents Use AI To See One Last Message From Their Deceased Son
'...what's to keep me from showing face, Man?'

Satoshi Tomizu Creates Pocket Universes And Worldcraft Bubbles In Glass
'The Worldcraft bubble glittered, catching the light...'

Space Hero Inc. Offers Trip To ISS As Reality Show Prize
'This is Elmer Schmitz, presenting to you the finalists in our Aviation Quiz Program...'

I Love Ceiling-Mounted Robots
'Immediately an enormous apparatus fell on to her out of the ceiling...'

Armano Remote Control Excavator
'The bulldozer moved through the... mine... '

OK, NASA 3D Printer Of Food Not Yet Star Trek Food Synthesizer
Maybe not, but we're seeing definite progress.

Kelly Clarkson Show Like Black Mirror '15 Million Merits'
'These people are pieces of software called avatars.'

Salto Jumping Robot Now Sticks Landing!
'Lucky touched the leap knob and the hopper's leg retracted.'

Gyroscopic Median-Straddling Mass Transit Vehicles
'It was among these leviathans that the little gyrocar was daring to thrust its puny self...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.