Phage-Assisted Continuous Evolution

Researchers have demonstrated that phage-assisted continuous evolution (PACE) can accelerate the development of therapeutic proteins for use in fighting cancer.


(PACE device
The evolution takes place in lagoons
(small red-capped bottles) that have been
seeded with bacteria-infecting viruses.
Bacteria flow in with the help of pumps
(on shelf) and then immediately flow out
into a waste container (clear rectangular tub).)

Most traditional pharmaceutical agents are small molecules, but a number of promising new therapies are based on macromolecules, such as proteins. So-called "directed evolution" gives scientists a way to adapt a naturally occurring macromolecule to perform a specific therapeutically useful function, such as bind to a cancer-linked protein.

"For some applications, the speed of conventional protein evolution is a bottleneck," says David Liu, a professor of chemistry and chemical biology at Harvard University and senior author of a paper describing the new technique in Nature. "Efforts to create proteins with tailor-made properties will be maximally useful if methods to create them can operate on a truly practical timescale..."

The new method also eliminates the cumbersome need for scientists to screen the entire library for successful variants during each round of evolution. PACE links the desired function to the production of a substance that the virus can't thrive without. If a single virus comes up with a version of the target protein that performs the desired function, that virus can complete its life cycle—which means its offspring will go on to infect other E. coli and continue the cycle. Subsequent rounds of evolution progress continually, automatically, and—because M13 has a life cycle of just 10 minutes—extremely quickly.

This idea is reminded me of a technique described by award-winning sf author Theodore Sturgeon in his classic 1941 story Microcosmic God. Sturgeon made use of tiny, short-lived creatures called Neoterics to solve problems for his protagonist, who put them under life-and-death pressure to force them to work for him.

Via Technology Review.

Scroll down for more stories in the same category. (Story submitted 4/19/2011)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Skin Electronics Can Show Electrocardiogram
'... the young men in the streets who applied polyimde OLED body film to their bared shoulders.' - Chen Qiufan, 2019.

Neurodevices For Consumers? Neuroethicists (And Philip K Dick) Say 'Caveat Emptor'
'They tried to use it today and it wouldn't work. No colors and no ceph patterns, neither one...' - Philip K. Dick, 1977.

BrainEx Restores Some Activity To Severed Pig Head
'... they placed the brain in a special solution, having all the properties of Nursing the brain cells.' - Edmond Hamilton, 1929.

Purdue Pharma Ready To Profit From OxyContin Use Or Addiction Recovery
'It may be organic damage. It may be permanent. Time'll tell, and only after you are off Substance D for a long while.' - Philip K. Dick, 1977.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Can We Comprehend Deep Learning Systems?
'You’ve nothing remotely like it, so I can’t describe it to you.'

Skin Electronics Can Show Electrocardiogram
'... the young men in the streets who applied polyimde OLED body film to their bared shoulders.'

Chinese Fern Helps Remediate Arsenic Soil
'Bioengeering had put out a spec report on the long crawly things five months back.'

Skai Air Taxi Costs The Same As Uber
'The air-taxi found its way past and around other ground-cars...'

Neurodevices For Consumers? Neuroethicists (And Philip K Dick) Say 'Caveat Emptor'
'They tried to use it today and it wouldn't work. No colors and no ceph patterns, neither one...'

NASA 3D Printed Habitat Challenge Won By AI SpaceFactory
3D printing - on Mars!

The Future Of Elon Musk's Neuralink
'Cerebral Electromagnetic Emmission Amplification and Relay System — call it artificial telepathy, if you like.'

Researchers Make You Say Anything in Videos
'[It] caused his televised image... to mouth the vowels and consonants beautifully.'

Jeff Bezos Tries Waldoes (Robotic Hands)
'Waldo put his arms into the primary pair before him...'

Asimov and Musk - Boring Company Tunnel vs. Street Race
'There was almost no sound, just a steady velvety whirr as the taxi sped along.'

Project Dylan - Amazon's Voice-Activated Wearable That Recognizes Human Emotions
Life imitates anime art.

Tesla Diagnoses Itself, Sends Part Request
'Tentacles emerged from the side of the machine and felt puzzledly at the damaged area.'

Lilium Electric Air Taxi Prototype
'The air-taxi found its way past and around other ground-cars...'

Swedes Premiere T-Pod Driverless Electric Truck
'the trucks gulped packages and scurried like beetles...'

HEL TVD Laser System To Be Built By Dynetics Lockheed Martin
'Forthwith flashes of actual flame, a bright glare leaping from one to another, sprang from the scattered group of men.'

Alcarelle Synthetic Alcohol Like Star Trek Synthehol
Bottoms up!

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.