Phage-Assisted Continuous Evolution

Researchers have demonstrated that phage-assisted continuous evolution (PACE) can accelerate the development of therapeutic proteins for use in fighting cancer.


(PACE device
The evolution takes place in lagoons
(small red-capped bottles) that have been
seeded with bacteria-infecting viruses.
Bacteria flow in with the help of pumps
(on shelf) and then immediately flow out
into a waste container (clear rectangular tub).)

Most traditional pharmaceutical agents are small molecules, but a number of promising new therapies are based on macromolecules, such as proteins. So-called "directed evolution" gives scientists a way to adapt a naturally occurring macromolecule to perform a specific therapeutically useful function, such as bind to a cancer-linked protein.

"For some applications, the speed of conventional protein evolution is a bottleneck," says David Liu, a professor of chemistry and chemical biology at Harvard University and senior author of a paper describing the new technique in Nature. "Efforts to create proteins with tailor-made properties will be maximally useful if methods to create them can operate on a truly practical timescale..."

The new method also eliminates the cumbersome need for scientists to screen the entire library for successful variants during each round of evolution. PACE links the desired function to the production of a substance that the virus can't thrive without. If a single virus comes up with a version of the target protein that performs the desired function, that virus can complete its life cycle—which means its offspring will go on to infect other E. coli and continue the cycle. Subsequent rounds of evolution progress continually, automatically, and—because M13 has a life cycle of just 10 minutes—extremely quickly.

This idea is reminded me of a technique described by award-winning sf author Theodore Sturgeon in his classic 1941 story Microcosmic God. Sturgeon made use of tiny, short-lived creatures called Neoterics to solve problems for his protagonist, who put them under life-and-death pressure to force them to work for him.

Via Technology Review.

Scroll down for more stories in the same category. (Story submitted 4/19/2011)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

New Brain Scanner Lets You Move Around
'In Bob Arctor's living room his thousand dollar custom-quality cephscope crafted by Altec...' - Philip K. Dick, 1977.

Ultrathin Brain Needle Developed At MIT
Putting drugs into a selected cubic millimeter within the living brain.

NASA's 'Armstrong' Soft Wearable Upper Extremity Garment
'Exact same articulation as your shoulder joint, and it holds your muscles out of the way...' - Samuel R. Delany, 1966.

iFlytek Doctor Robot First To Pass Medical Exams
No problem, we'll just use the autodoc.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

IBM's Grain Of Sand Computer
'Our ancestors... thought to make the very sand beneath their feet intelligent...'

Liquid Metal Shape-Changing 'Soft Robotics'
'A mimetic poly-alloy... 'What the hell does that mean?''

The Hammock Caravan And Italo Calvino's Octavia
'Now I will tell you how Octavia, the spider-web city, is made.'

Super-Resolution Microscopy Provides '4D' Views
View the magnified interior of living cells.

Have I Seen The Tesla Roadster Story Before?
'Only it wasn't a vessel. It was an automobile...'

Watch 'Do You Trust This Computer' For Free Today
Thanks for making this available, Elon.

Self-Driving Car Ticketed
This just missed making my day.

Elon Musk Tweets Versions Of Clarke's Operation Cleanup
'Fortunately, the old orbital forts were superbly equipped for this task.'

Burner Generates Temporary Phone Numbers
'Interesting phone system he's got, by the way...'

Walmart’s Autonomous Robot Bees
Everyone loves bees.

EA Created AI That Taught Itself To Play Battlefield
Harmless fun for computer scientists.

Is Teleportation A Death Sentence?
'A long trail of dead, he thought, left across the stars...'

New Brain Scanner Lets You Move Around
'In Bob Arctor's living room his thousand dollar custom-quality cephscope crafted by Altec...'

Can An Entire Brain Be Simulated In A Computer?
'The miles of relays and photocells had given way to the spongy globe of platinum iridium about the size of the human brain.'

Physicists Try To Turn Light Into Matter
If E=mc squared, then... m=E/c squared!

Save Your Brain's Connectome, Upload Yourself Elsewhere
'You've got remote storage. How regular is the update?'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.