Deleting Gene Makes Mice Smarter

Disabling the RGS14 gene in mice improves their ability to learn and remember, according to a study published by Emory University's School of Medicine researchers.

The researchers were surprised to find that, in mice with a disabled RGS14 gene, the CA2 region was now capable of "robust" long-term potentiation, meaning that in response to electrical stimulation, neurons there had stronger connections. On top of that, the ability of the gene-altered mice to recognize objects previously placed in their cages was enhanced, compared to normal mice. They also learned more quickly to navigate through a water maze to a hidden escape platform by remembering visual cues.

"A big question this research raises is why would we, or mice, have a gene that makes us less smart a Homer Simpson gene?" John Hepler, PhD, professor of pharmacology at Emory University School of Medicine, says. "I believe that we are not really seeing the full picture. RGS14 may be a key control gene in a part of the brain that, when missing or disabled, knocks brain signals important for learning and memory out of balance."

The lack of RGS14 doesn't seem to hurt the altered mice, but it is still possible that they have their brain functions changed in a way that researchers have not yet been able to spot. Besides being resistant to injury by seizure, certain types of CA2 neurons are lost in schizophrenia, and loss of another gene turned on primarily in the CA2 region leads to altered social behaviors,

RGS14, which is also found in humans, was identified more than a decade ago.

Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.


(Flowers For Algeron)

Read more at RDMag; thanks to Winchell Chung for prodding me to do this article.

Scroll down for more stories in the same category. (Story submitted 9/23/2010)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 4 )

Related News Stories - (" Biology ")

China Melts Tibetan Permafrost To Plant Forest
'Can you give us a microwave spotlight?' - Niven, Pournelle, Flynn, 1995.

Hackers Insert Malware Into DNA
'They tied the memory to the bloodline and that was their record!' -

Worms Eat Plastic Now
'Slowly and inexorably, the rate of dissolution increased...' - Davis/Pedlar, 1971.

Mini-Brains In A Dish
'Cultured brains on a slab.' - Peter Watts, 1999.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

China Melts Tibetan Permafrost To Plant Forest
'Can you give us a microwave spotlight?'

iFlytek Doctor Robot First To Pass Medical Exams
Doctor shortage? No problem, we'll just use the autodoc.

Slaughterbot AI KIller Quadcopter Drones
'The real border was defended by... a swarm of quasi-independent aerostats.'

Do We Really Want Backflipping Robots?
Also includes wonderful blooper reel.

RNA-Based Biocomputing Device
Living things can sense and analyze complex signals in living cells.

Seasteading Floating Cities
'It was a remarkable island, circular, about half a kilometer in diameter.'

Tesla Semi 'Electrotruck' Unveiled
Elon Musk unveils yet another technological marvel.

Watch What People Are Seeing Via Brain Scanning
'had managed to see through the other man's eyes as the other man, all unaware, washed their Zis limousine sixteen hundred meters away...'

Integrated Circuits Printed Right Onto Fabric!
'...a shirt that displayed email on its sleeve.

Interstellar Asteroid Visits Our Solar System
'This asteroid had whirled in from the cold of the interplanetary space...'

PRIMA Bionic Vision Restoration
'The VISOR... was a medical device used in the Federation to aid patients who have suffered loss of eyesight...'

Audi Traffic Jam Pilot Knows If You're Sleeping
'Even here, riding a garbage truck to eternity, the machine watched him...'

UM Hall Thruster Breaks Records
Someday, we'll see an ion drive used to get to Mars.

Ionity Ultra-fast Charging Station Network
'Recharge the batteries... in almost every town and village...'

VAuth Voice Security Wearable From University of Michigan
'Siri, I gave you a voice command...' 'Yes, but do I know you?'

Ubiquiti FrontRow Camera Records Your Life
Why be choosy? Just upload your whole life to the Internet, and be done with it.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.