Deleting Gene Makes Mice Smarter

Disabling the RGS14 gene in mice improves their ability to learn and remember, according to a study published by Emory University's School of Medicine researchers.

The researchers were surprised to find that, in mice with a disabled RGS14 gene, the CA2 region was now capable of "robust" long-term potentiation, meaning that in response to electrical stimulation, neurons there had stronger connections. On top of that, the ability of the gene-altered mice to recognize objects previously placed in their cages was enhanced, compared to normal mice. They also learned more quickly to navigate through a water maze to a hidden escape platform by remembering visual cues.

"A big question this research raises is why would we, or mice, have a gene that makes us less smart a Homer Simpson gene?" John Hepler, PhD, professor of pharmacology at Emory University School of Medicine, says. "I believe that we are not really seeing the full picture. RGS14 may be a key control gene in a part of the brain that, when missing or disabled, knocks brain signals important for learning and memory out of balance."

The lack of RGS14 doesn't seem to hurt the altered mice, but it is still possible that they have their brain functions changed in a way that researchers have not yet been able to spot. Besides being resistant to injury by seizure, certain types of CA2 neurons are lost in schizophrenia, and loss of another gene turned on primarily in the CA2 region leads to altered social behaviors,

RGS14, which is also found in humans, was identified more than a decade ago.

Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.


(Flowers For Algeron)

Read more at RDMag; thanks to Winchell Chung for prodding me to do this article.

Scroll down for more stories in the same category. (Story submitted 9/23/2010)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 4 )

Related News Stories - (" Biology ")

Amazing 'Hybrid' Solar-Powered Sea Slug Does Photosynthesis
Thank goodness for Star Trek.

Should You Submit Your DNA To A Database?
Consumer DNA services are often inaccurate.

Humans Evolve Deep Diving Abilities
Sounds like '60s sci-fi to me.

Researchers Create Bowls, Coils, Ripples Of Living Tissue
'... biological robots were not living creatures.' - Arthur C. Clarke, 1972.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

 

Current News

Ontario Starts Guaranteed Minimum Income
'Earned by just being born.'

Is There Life In Outer Space? Will We Recognize It?
'The antennae of the Life Detector atop the OP swept back and forth...'

Space Traumapod For Surgery In Spacecraft
' It was a ... coffin, form-fitted to Nessus himself...'

Tesla Augmented Reality Hypercard
'The hypercard is an avatar of sorts.'

A Space Ship On My Back
''Darn clever, these suits,' he murmured.'

Biomind AI Doctor Mops Floor With Human Doctors
'My aim was just not to lose by too much.' - Human Physician participant.

Fuli Bad Dog Robot Is 'Auspicious Raccoon Dog' Bot
Bad dog, Fuli. Bad dog.

Las Vegas Humans Ready To Strike Over Robots
'A worker replaced by a nubot... had to be compensated.'

You'll Regrow That Limb, One Day
'... forcing the energy transfer which allowed him to regrow his lost fingers.'

Elon Musk Seeks To Create 1941 Heinlein Speedster
'The car surged and lifted, clearing its top by a negligible margin.'

Somnox Sleep Robot - Your Sleepytime Cuddlebot
Science fiction authors are serious about sleep, too.

Real-Life Macau or Ghost In The Shell
Art imitates life imitates art.

Has Climate Change Already Been Solved By Aliens?
'I had explained," said Nessus, "that our civilisation was dying in its own waste heat.'

First 3D Printed Human Corneas From Stem Cells
Just what we need! Lots of spare parts.

VirtualHome: Teaching Robots To Do Chores Around The House
'Just what did I want Flexible Frank to do? - any work a human being does around a house.'

Messaging Extraterrestrial Intelligence (METI) Workshop
SF writers have thought about this since the 19th century.

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.