 |
Rapamycin Can Repair Specific Learning Deficits
Rapamycin, a drug approved by the FDA to stop tissue rejection after organ transplants, has been found to reverse the brain dysfunction caused by a genetic disease - tuberous sclerosis complex (TSC).
"These findings challenge the theory that abnormal brain development is to blame for mental impairment in tuberous sclerosis," added first author Dan Ehninger, postgraduate researcher in neurobiology. "Our research shows that the disease's learning problems are caused by reversible changes in brain function -- not by permanent damage to the developing brain."
TSC often causes severe mental retardation; half of all TSC patients also suffer from autism and epilepsy. The disorder afflicts about one in 6,000 people - twice as common as Huntington's or Lou Gehrig's disease.
"After only three days of treatment, the TSC mice learned as quickly as the healthy mice," said Ehninger. "The rapamycin corrected the biochemistry, reversed the learning deficits and restored normal hippocampal function, allowing the mice's brains to store memories properly."
Science fiction fans may be reminded of the technique used in the Hugo award-winning short story Flowers for Algernon, published in 1959 in The Magazine of Fantasy and Science Fiction by Daniel Keyes. In the story, a lab mouse has undergone a new kind of surgery to increase intelligence. The first human test subject, a mildly retarded man named Charlie, writes a set of brief diary entries that form the story.
"This is the first study to demonstrate that the drug rapamycin can repair learning deficits related to a genetic mutation that causes autism in humans. The same mutation in animals produces learning disorders, which we were able to eliminate in adult mice," explained principal investigator Dr. Alcino Silva, professor of neurobiology and psychiatry at the David Geffen School of Medicine at UCLA. "Our work and other recent studies suggest that some forms of mental retardation can be reversed, even in the adult brain."
Silva and Ehninger studied mice bred with TSC and verified that the animals suffered from the same severe learning difficulties as human patients. Next, the UCLA team traced the source of the learning problems to biochemical changes sparking abnormal function of the hippocampus, a brain structure that plays a key role in memory.
"Memory is as much about discarding trivial details as it is about storing useful information," said Silva, a member of the UCLA Department of Psychology and UCLA Brain Research Institute. "Our findings suggest that mice with the mutation cannot distinguish between important and unimportant data. We suspect that their brains are filled with meaningless noise that interferes with learning."
(Flowers For Algeron - a book cover you may remember)
Via EurekAlert!; thanks to Moira for the tip and the reference.
Scroll down for more stories in the same category. (Story submitted 7/16/2008)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion (Back On) ( 2 )
Related News Stories - (" Medical ")
CARMAT Bioprosthetic Total Human Heart Replacement
'George Walt's corporate existence proved the workability of wholly mechanical organs...'- Philip K. Dick, 1964.
Physical Exam? We've Got Apps
See the future of handheld, personal medical devices used with your smartphone.
Japan's Nursing Home Robot Plan
Let's make the Roujin Z-0001 Robotic Bed!
Mini-Livers Made By 3D Printer
Organlegging may not be the growth industry that some fear.
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Current News
MIT Robot Cheetah Video Shows Gait Transition
'The legs are long, curled way up to deliver power, like a cheetah's.'
TrackingPoint Smart Rifle
Not your typical 'smart bullet' approach.
'Hello, Computer!' Google Now Highlighted at IO13
'Hello, computer!'
Sky City's 220 Stories Are Go
'It rested among green parklands and... stood in total isolation, a glittering block of whites and flashing windows dotted with colors.'
CARMAT Bioprosthetic Total Human Heart Replacement
'George Walt's corporate existence proved the workability of wholly mechanical organs...'
Personal Sniffer Robots
'...The ticking combinations of the olfactory system of the hound.'
Physical Exam? We've Got Apps
See the future of handheld, personal medical devices.
The Interplanetary Internet, Vint Cerf Speaking
'This was the center of Interplanetary Communications.'
Drosophila Robotica, The Mechanical Fly
'... the Scarab [flying robot] buzzed into the great workroom as any intruding insect might...'
Robo-Raven Flapping Wing Robot Bird
'When he had first built them, they had been crude indeed, flying mechanisms with little more than a reflex-response unit.'
Japan's Nursing Home Robot Plan
Let's make the Roujin Z-0001 Robotic Bed!
Samsung Smart TVs With Gesture Control
'He waved his hand and the circuit switched abruptly.'
Swiss HCPVT Giant Photovoltaic 'Flower'
'...leaning against one of the slender stalks of a sunshade-photocell collector.'
Mini-Livers Made By 3D Printer
Organleggers may experience an employment downturn.
Smartphone Sensor System Tracks Gunfire
'Sound trackers on the roof could zero in on weapons action...'
Bacteria Now Make Biofuel Like Oil
'They have ... germs that eat pretty near anything, and produce oil as a waste product.'
