 |
'Volume Control' Ear Protein Uncovered
The nAChR protein found on sensory hair cells in the ear has been found to be a 'volume control' for the hearing system. It is part of a system that allows the ear to turn itself down to protect against permanent hearing loss.
The team genetically altered a single building block in the nAChR protein and tested mice for their ability to hear. "This point mutation was designed to produce a so-called gain of function in which the inhibitory effect of ACh should be greater than normal," says Fuchs.
The altered mice were less able to hear soft sounds than normal mice, showing that the genetic alteration made in the nAChR protein did indeed further "turn down" the ear. The team then asked if the alteration in nAChR, and therefore the improved sound-blocking ability of these altered mice, also could protect from sound damage.
After blasting mice with 100-decibel sound, mice with the altered nAChR suffered less permanent hearing damage compared to normal mice. One of the study's authors, Paul Fuchs, Ph.D., professor of otolaryngology-head and neck surgery and co-director of the Center for Sensory Biology at the Institute for Basic Biomedical Sciences at Johns Hopkins, commented that there was "a real chance of finding ear-specific drugs in the future."
Writer Larry Niven remarks on this ability in his 1966 novel World of Ptavvs (I don't know if it was present in the novella published in 1965):
Here's another quote from A Gift From Earth (1968):
Via Eurekalert; thanks to an anonymous reader for pointing out the article and the sf connection (I hope I found the one you mentioned). Also, see another hundred or so ideas and inventions from the mind of Larry Niven.
To get a better handle on this sound-limiting system in the ear, the research team built on previous findings in the field and focused their efforts on the nAChR protein found on so-called sensory hair cells in the ear. Nerve cells from the brain release signals that are picked up by nAChR and turn down these sensory hair cells.
As he left the elevator Luke met the usual continuous roar. He waited ten seconds while his ears "learned" to ignore it; an essential mechanism, learned by most children before they were three.
The noise hit them as they opened the door. Matt stood still while his ears adjusted to the noise level - a survival trait his ancestors had developed when Earth's population numbered nineteen billion, even as it did that night, eleven point nine light-years away.
Scroll down for more stories in the same category. (Story submitted 1/22/2009)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion (Back On) ( 2 )
Related News Stories - (" Biology ")
Bacteria Now Make Biofuel Like Oil
'They have ... germs that eat pretty near anything, and produce oil as a waste product.'- Hal Clement, 1950.
Youthful Brain With A Flip Of A Molecular Switch
I need all the brain plasticity I can get.
Human 'Quadruple Helix' DNA
'Their genetic structure, based on the quadruple sterated octohelix...'- Douglas Adams, 1978.
The Plastic Eaters - Amazon Fungus Lives On Plastic
'the smell of the rotting plastic began to hang permanently in the air...'- Davis/Pedlar, 1971
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Current News
MIT Robot Cheetah Video Shows Gait Transition
'The legs are long, curled way up to deliver power, like a cheetah's.'
TrackingPoint Smart Rifle
Not your typical 'smart bullet' approach.
'Hello, Computer!' Google Now Highlighted at IO13
'Hello, computer!'
Sky City's 220 Stories Are Go
'It rested among green parklands and... stood in total isolation, a glittering block of whites and flashing windows dotted with colors.'
CARMAT Bioprosthetic Total Human Heart Replacement
'George Walt's corporate existence proved the workability of wholly mechanical organs...'
Personal Sniffer Robots
'...The ticking combinations of the olfactory system of the hound.'
Physical Exam? We've Got Apps
See the future of handheld, personal medical devices.
The Interplanetary Internet, Vint Cerf Speaking
'This was the center of Interplanetary Communications.'
Drosophila Robotica, The Mechanical Fly
'... the Scarab [flying robot] buzzed into the great workroom as any intruding insect might...'
Robo-Raven Flapping Wing Robot Bird
'When he had first built them, they had been crude indeed, flying mechanisms with little more than a reflex-response unit.'
Japan's Nursing Home Robot Plan
Let's make the Roujin Z-0001 Robotic Bed!
Samsung Smart TVs With Gesture Control
'He waved his hand and the circuit switched abruptly.'
Swiss HCPVT Giant Photovoltaic 'Flower'
'...leaning against one of the slender stalks of a sunshade-photocell collector.'
Mini-Livers Made By 3D Printer
Organleggers may experience an employment downturn.
Smartphone Sensor System Tracks Gunfire
'Sound trackers on the roof could zero in on weapons action...'
Bacteria Now Make Biofuel Like Oil
'They have ... germs that eat pretty near anything, and produce oil as a waste product.'
