Science Fiction Dictionary
A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

 

Complete Human Skin Grown From Stem Cells

Complete human skin epidermis has been successfully grown skin-derived stem cells on laboratory mice. This advance could lead to production of one's own skin (an autologous transplant) without the immediate need to harvest the skin from other areas of the body.


(Complex structure of human epidermis)

Background
Cell therapy for large burns is dependent upon autologous epidermis reconstructed in vitro. However, the effectiveness of current procedures is limited by the delay needed to culture the patient's own keratinocytes. To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.

Methods
hESCs from lines H9 and SA01 were seeded at least in triplicate on fibroblast feeder cells for 40 days in a medium supplemented with bone morphogenetic protein 4 and ascorbic acid. Molecular characterisation of cell differentiation was done throughout the process by quantitative PCR, fluorescence-activated cell sorting, and immunocytochemical techniques. Keratinocyte molecular differentiation and functional capacity to construct a human epidermis were assessed in vitro and in vivo.

Findings
From hESCs, we generated a homogeneous population of cells that showed phenotypic characteristics of basal keratinocytes. Expression levels of genes encoding keratin 14, keratin 5, integrin α6, integrin β4, collagen VII, and laminin 5 in these cells were similar to those in basal keratinocytes. After seeding on an artificial matrix, keratinocytes derived from hESCs (K-hESCs) formed a pluristratified epidermis. Keratin-14 immunostaining was seen in the basal compartment, with keratin 10 present in layers overlying the basal layer. Involucrin and filaggrin, late markers of epidermal differentiation, were detected in the uppermost layers only. 12 weeks after grafting onto five immunodeficient mice, epidermis derived from K-hESCs had a structure consistent with that of mature human skin. Human involucrin was appropriately located in spinous and granular layers and few Ki67-positive cells were detected in the basal layer.

Interpretation
hESCs can be differentiated into basal keratinocytes that are fully functional—ie, able to construct a pluristratified epidermis. This resource could be developed to provide temporary skin substitutes for patients awaiting autologous grafts.

Artificial skin is a science fiction staple; see the surrogate skin from Robert Heinlein's 1951 novel The Puppet Masters and art-derm from Philip K. Dick's 1961 novel Dr. Futurity and the more functional read-out skin from John Varley's 1992 novel Steel Beach.

Looking for more real-life artificial skin alternatives? I've got you covered:

From The Lancet via medGadget.

Scroll down for more stories in the same category. (Story submitted 12/3/2009)

Follow this kind of news @Technovelgy.

| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |

Would you like to contribute a story tip? It's easy:
Get the URL of the story, and the related sf author, and add it here.

Comment/Join discussion ( 0 )

Related News Stories - (" Medical ")

Forward CarePod The AI Doctor's Office
'It's an old model,' Rawlins said. 'I'm not sure what to do.'

Octopus Suckers Inspire Transdermal Patches
'...a capsule which he placed against his wrist.' - Philip K. Dick, 1960.

'Droplet' Battery Microscale Power Pack
'...a power pack the size of a pea.' - Alfred Bester, 1956.

Who Needs Asimov's 'Proteus' When You Can Have Pangolins?
'The Proteus was still falling, still shrinking...' - Isaac Asimov, 1966.

 

Google
  Web TechNovelgy.com   

Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.

 

 

 

 

Science Fiction Timeline
1600-1899
1900-1939
1940's   1950's
1960's   1970's
1980's   1990's
2000's   2010's

Current News

Russians Think US Is Weaponizing Asteroids
'BY PUSHING AGAINST THE LITTLE MARTIAN MOON WITH OUR ROCKET SHIP, WE HAD LESSENED THE CENTRIFUGAL SPEED THAT HELD IT BALANCED IN THE SKY.'

The Warp And Fabric Of Spacetime
'Jenkins had evidently fallen into a warp in space.'

'Birds Aren't Real' An NPR Gen-Z Conspiracy
Keep your eyes on the skies!

Wearable Energy Harvester
'... he had tightened the chest to gain maximum pumping action from the motion of breathing.'

Drones Participate In Buddhist Rites
'...a prayer wheel swung into view and began spinning at a furious pace.'

Anna Indiana AI Singer-Songwriter
'She is a personality-construct, a congeries of software agents'

Video Manicuring ala Schismatrix
'The program raced up the screen one scan line at a time'

'Feel the AGI' OpenAI Leader Now OpenWorship
'And are all the people willing to be governed by a machine?'

NASA Tests Prototype Europa Lander
Why have legs if they don't walk around?

Tailsitter Drone Aircraft For SAR
'...it was so easy for me to remain motionless in midair.'

Forward CarePod The AI Doctor's Office
'It's an old model,' Rawlins said. 'I'm not sure what to do.'

Mika The Robot-Boss
'the robot-boss was busy at the lip of the new lode instructing and egging the men on to greater speed...'

Yamaha Motoroid 2 No Handlebars Self-Balancing Motorcycle
'He rode the bike with an intense lack of physical grace...'

San Francisco Autobus
'THE autobus turned silently down the wide street...'

Should Your Car Decide If You Can Drive?
'Okay. Maybe the car was right...'

Lucid Dreams On Demand From Prophetic and Card79
'the peeper did not operate by virtue of its machinery alone, but by the reaction of the brain and the body of its user...'

More SF in the News Stories

More Beyond Technovelgy science news stories

Home | Glossary | Invention Timeline | Category | New | Contact Us | FAQ | Advertise |
Technovelgy.com - where science meets fiction™

Copyright© Technovelgy LLC; all rights reserved.