Science Fiction
Dictionary
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
 |
Logic Gates Built Inside Living Cells
Caltech scientists announced that they had succeeded in building synthetic RNA logic gates inside living cells that actually sense molecules inside the cell.
The end result is that the drug acts as a switch, turning the ribozyme on and off. Making each of the two lobes sensitive to a different drug even created a biological AND switch; both drugs need to be present for an active ribozyme. But a ribozyme isn't necessarily easy to detect, so the authors made it obvious: they inserted their logic gates into a gene that encodes a messenger RNA that produces the Green Fluorescent protein (the protein that recently won folks a Nobel Prize). Now, when the ribozyme is active, the messenger RNA gets broken up and no GFP is made; otherwise, the cells glow green.
This setup allowed the creation of an OR logic system as well.
Several RNA sequences have been identified that bind small molecules, like the drug tetracycline. The authors inserted these into the extended lobes, such that the drug controlled the folding of the RNA. When tetracycline is present, the RNA would fold so that there was no active ribozyme. Remove the tetracycline, and the molecule would reshuffle so that the ribozyme became active.
(Signal Integration Schemes)
This advance could lead to a wide range of applications, since the method would work just as well inside the cells of mammals. Biocomputers in a human bloodstream could control "smart drugs" that activate only under particular circumstances. Sensor cells could be programmed to detect the precursors of diseases like cancer, and then "light up" to alert health care professionals.
SF writer Greg Bear wrote about this idea in his 1984 novel Blood Music; he called them "biologics:"
Why limit oneself to silicon and protein and biochips a hundreth of a millimeter wide, when in almost every living cell there was already a functioning computer with a huge memory?
Let's hope we don't wind up with what Bear called intellectual cells. From RNA-based logic gates compute inside cells.
Scroll down for more stories in the same category. (Story submitted 10/19/2008)
Follow this kind of news @Technovelgy.| Email | RSS | Blog It | Stumble | del.icio.us | Digg | Reddit |
Would
you like to contribute a story tip?
It's easy:
Get the URL of the story, and the related sf author, and add
it here.
Comment/Join discussion ( 0 )
Related News Stories - (" Biology ")
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.' - John Varley, 1977.
Let's Make Slaver Sunflowers! Engineering Plants To Reflect Light
'The mirror-blossom was a terrible weapon.' - Larry Niven, 1965.
Machete-Wielding Philodendron Isn't Going To Take It Anymore
'The tree ended its wild larruping, stood like a dreaming giant liable to wake into frenzy at any moment.' - Eric Frank Russell, 1943.
Tsunami Forecasts Improved By Ionosphere Signals
'Swifter than any tide could ebb, the water was receding from the shore.'
Technovelgy (that's tech-novel-gee!) is devoted to the creative science inventions and ideas of sf authors. Look for the Invention Category that interests you, the Glossary, the Invention Timeline, or see what's New.
Science Fiction
Timeline
1600-1899
1900-1939
1940's 1950's
1960's 1970's
1980's 1990's
2000's 2010's
Current News
Mushroom 'Robot' Is Just A Start
'Some unknown race ... decided to help them out.'
Tesla Electric 'Giga Train' Operational In Germany
'...the cars are wedge-shaped at both ends.'
DOTPad Braille Device Offers Live Access
Amazing tactile display.
Biohybrid Robot Combines Living Muscle With Artificial Materials
'...great rectangular slabs of muscle, slung into a rectangular frame.'
Biohybrid Robots Made Of Living And Synthetic Materials
'If the biological robots were not living creatures, they were certainly very good imitations.'
Drug Induces Hibernation-Like State In Humans
'... drugged and chilled and stowed in sleep tanks.'
Poul Anderson's 'Brain Wave'
"Everybody and his dog, it seemed, wanted to live out in the country; transportation and communication were no longer isolating factors."
AI Note-Taking From Google Meet
'... the new typewriter that could be talked to, and which transposed the spoken sound into typed words.'
Qore IcePlates Are Personal Cooling Suits
'... underneath they consisted of networks of cooling tubes against the skin.'
P1 Just The Latest Robot To Take A Beating From Humans
'...we mere people come second.'
Waymo Cars Shout At Each Other, Autonomously
'My cars talk to one another. I have no doubt about it...'
Your Solar Electric Paint Is Ready, Larry Niven
'...you spray it on.'
How Long Till We Have These Tattoos?
Truth or fiction?
Seeing Faces On Grains Of Sand (AI Pareidolia)
'... the imprint of her image on the telephoto cell.'
Lunar Biorepository Proposed For Cryo-Preservation Of Earth Species
'...there was no one alive who had ever seen them. But they existed in the Life Bank.'
Tele-Driving Offers Jobs For Tele-Drivers, Not AIs
''...some bored drone pusher in a remote driving centre...'
